CP61-TAT
CP61-TAT is a CtBP1/CtBP2 inhibitor. CP61-TAT enters cells via TAT-mediated delivery and disrupts CtBP1/CtBP2 dimerization and nuclear co-localization, thereby inducing aberrant mitosis and micronucleus formation and inhibiting cell proliferation and colony-forming potential. CP61-TAT can be used for research on breast cancer.
For research use only. We do not sell to patients.
- Formula: C123H207N49O28S3
- Molecular Weight:2916.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CtBP1 |
CtBP2 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:50 μM
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Incubation Time:48 h
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Result:Reduced clonogenic survival of MCF-7 cells approximately 3-fold.
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Cell Line:MCF-7 cells
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Concentration:50 μM; 100 μM
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Incubation Time:48 h
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Result:Increased aberrant mitosis with 27.5% aberrant mitoses and a 71% increase in cell number over 48 h.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
- Genotoxicity/Mutagenicity Study
Chemical Information
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Molecular Weight 2916.47
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Formula C123H207N49O28S3
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SMILES
O=C(NCC(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@H]3CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N)NC3=O
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Sequence
cyclo(Cys-Gly-Trp-Thr-Val-Val-Arg-Met-Tyr)-Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln (disulfide bridge:Cys1-Cys10)
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Sequence Shortening
cyclo(CGWTVVRMY)-CGRKKRRQRRRPPQ (disulfide bridge:Cys1-Cys10)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP61-TAT Related Classifications
HY-P12401 Related Classifications
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