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Cat. No.: HY-P10301

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CXCL9(74-103)

Name: CXCL9(74-103)
Brand: MedChemExpress
SKU: HY-P10301
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

CXCL9(74-103) is a derivative peptide of CXCL9 that has a high affinity for glycosaminoglycans (GAGs) and can bind to GAGs. CXCL9(74-103) possesses anti-angiogenic properties, capable of reducing EGF, VEGF165, and FGF-2-mediated angiogenesis processes in vitro, without exhibiting cytotoxicity.

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Formule: C₁₅₈H₂₉₅N₅₉O₄₀
Masse moléculaire:3661.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

CXCL9(74-103) Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vivo
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Description

Voir tous les produits spécifiques à Isoform CXCR :

In Vitro

CXCL9(74-103) (0.3-3 μM; 3-4 days) reduces growth factor-induced endothelial cell proliferation, migration, (0.3-3 μM; 15 min) adhesion, and spheroid sprouting in HMVECs. CXCL9(74-103) (0.3-3 μM; 24 h) is not cytotoxic in HMVECs^[1].
CXCL9(74-103) (3 μM) interferes with growth factor signaling by reducing VEGF165 binding to HS and directly binding to FGF-2, and relies on cell surface HS binding to endothelial cells to exert its anti-angiogenic activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CXCL9(74-103) (subcutaneously implanted osmotic pump containing 400 µg/100 µL) significantly reduces FGF-2-induced Matrigel plug angiogenesis in C57BL/6 mice. CXCL9(74-103) (administered as 10 μL drops of 100 μg/mL, once daily for 4 days) reduces pathological blood vessel growth in the corneal burn model of C57BL/6 mice. CXCL9(74-103) (subcutaneously implanted osmotic pump containing 800 µg/100 µL, delivering a continuous dose over the course of two weeks) attenuates tumor angiogenesis in MDA-MB-231 breast cancer SCID mice. Additionally, CXCL9(74-103) also reduces vascular leakage in the retina of diabetic rats, demonstrating its anti-angiogenic effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 3661.40
Formule C₁₅₈H₂₉₅N₅₉O₄₀
Sequence

Lys-Lys-Lys-Gln-Lys-Asn-Gly-Lys-Lys-His-Gln-Lys-Lys-Lys-Val-Leu-Lys-Val-Arg-Lys-Ser-Gln-Arg-Ser-Arg-Gln-Lys-Lys-Thr-Thr
Sequence Shortening

KKKQKNGKKHQKKKVLKVRKSQRSRQKKTT
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Cell Death Dis

Ripk2 promotes CD8+ T cell inactivation and hepatocellular carcinoma progression through Myb/Cxcl9 and Pax5/Adpgk signaling pathways. [Abstract]

2026 May 29. PMID: 42215445

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. De Zutter A, et al. The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors. Cancers (Basel). 2021;13(20):5090. Published 2021 Oct 12. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CXCL9(74-103)

1 Cited Publications

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CXCL9(74-103)

Publications Citing Use of MedChemExpress (MCE) CXCL9(74-103)

Voir tous les produits spécifiques à Isoform CXCR

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Chemical Information

Publications (1)

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CXCL9(74-103) Related Classifications

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