CXCL9(74-103)
CXCL9(74-103) is a derivative peptide of CXCL9 that has a high affinity for glycosaminoglycans (GAGs) and can bind to GAGs. CXCL9(74-103) possesses anti-angiogenic properties, capable of reducing EGF, VEGF165, and FGF-2-mediated angiogenesis processes in vitro, without exhibiting cytotoxicity.
For research use only. We do not sell to patients.
- Formula: C158H295N59O40
- Molecular Weight:3661.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CXCL9(74-103) (0.3-3 μM; 3-4 days) reduces growth factor-induced endothelial cell proliferation, migration, (0.3-3 μM; 15 min) adhesion, and spheroid sprouting in HMVECs. CXCL9(74-103) (0.3-3 μM; 24 h) is not cytotoxic in HMVECs[1].
CXCL9(74-103) (3 μM) interferes with growth factor signaling by reducing VEGF165 binding to HS and directly binding to FGF-2, and relies on cell surface HS binding to endothelial cells to exert its anti-angiogenic activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 3661.40
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Formula C158H295N59O40
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Sequence
Lys-Lys-Lys-Gln-Lys-Asn-Gly-Lys-Lys-His-Gln-Lys-Lys-Lys-Val-Leu-Lys-Val-Arg-Lys-Ser-Gln-Arg-Ser-Arg-Gln-Lys-Lys-Thr-Thr
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Sequence Shortening
KKKQKNGKKHQKKKVLKVRKSQRSRQKKTT
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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