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Cat. No.: HY-160621

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CXF-009

CXF-009 is a selective and covalent FGFR4 inhibitor, with the IC₅₀ of 48 nM. CXF-009 targeting Cys477 and Cys552 of FGFR4, and can be used for the study of hepatocellular carcinoma.

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CAS No.: 2727084-00-4
Formule: C₃₃H₃₈N₈O₅
Masse moléculaire:626.71

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CXF-009 Chemical Structure

CAS No.: 2727084-00-4

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CXF-009 is a selective and covalent FGFR4 inhibitor, with the IC₅₀ of 48 nM. CXF-009 targeting Cys477 and Cys552 of FGFR4, and can be used for the study of hepatocellular carcinoma^[1].

IC₅₀ & Target

FGFR4

48 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>5000 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	1562 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	1971 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	38 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	777 nM Compound: CXF-009	Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
HCC1937	IC₅₀	>10 μM Compound: CXF-009	Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Hep 3B2	IC₅₀	0.9 μM Compound: CXF-009	Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Huh-7	IC₅₀	0.73 μM Compound: CXF-009	Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
MDA-MB-453	IC₅₀	0.73 μM Compound: CXF-009	Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay	[PMID: 38432058]

Chemical Information

CAS No. 2727084-00-4
Masse moléculaire 626.71
Formule C₃₃H₃₈N₈O₅
SMILES

O=C(NC1=C(NC2=NC=C3C(N(CCCN4CCN(CC4)C(C=C)=O)C(N(C3)C5=CC(OC)=CC(OC)=C5)=O)=N2)C=CC=C1)C=C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen X, et al. Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem. 2022;5(1):36. Published 2022 Mar 17. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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