Cys-CPP44
Cys-CPP44 is a cell-penetrating peptide with a Cys introduced at the N-terminus, which can specifically penetrate hepatocellular carcinoma cells. Modification with Cys-CPP44 promotes the specific penetration of arsenic trioxide-loaded liposomes into hepatocellular carcinoma cells and enhances the cellular uptake of liposomes by these cells. Cys-CPP44 can be used for the research of hepatocellular carcinoma.
For research use only. We do not sell to patients.
- Formula: C94H147N29O21S3
- Molecular Weight:2115.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cys-CPP44 forms DSPE-PEG-MAL-CPP44 conjugate whose successful synthesis is verified by MALDI-TOF-MS at m/z = 5042.349[1].
Cys-CPP44 significantly elevates the uptake efficiency of modified liposomes (CPP44-Lp) in HepG2 cells compared with unmodified liposomes[1].
Cys-CPP44-modified ATO liposomes (CPP44-ATO-Lp) significantly reduce the viability of HepG2 cells compared with free ATO and unmodified ATO-Lp; after incubation with 0.05 μM ATO for 24 h, the total apoptosis rate of HepG2 cells reaches 25.48%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cys-CPP44 paired with anti-GPC3 antibody constructs dual-ligand liposomes (1 mg/kg; intravenous injection; single administration), which display enhanced tumour-targeted accumulation and prolonged retention in orthotopic hepatocellular carcinoma tumours of BALB/c nu/nu mice, with 1.43-fold higher tumour fluorescence intensity at 24 h post-administration relative to unmodified liposomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 2115.55
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Formula C94H147N29O21S3
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Sequence
CKRPTMRFRYTWNPMK
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Sequence Shortening
Cys-Lys-Arg-Pro-Thr-Met-Arg-Phe-Arg-Tyr-Thr-Trp-Asn-Pro-Met-Lys
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cys-CPP44 Related Classifications
HY-P11926 Related Classifications
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