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Cat. No.: HY-150135

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D-myo-Inositol-1,4,5-triphosphate

Name: D-myo-Inositol-1,4,5-triphosphate
Brand: MedChemExpress
SKU: HY-150135
Availability: PreOrder

(Synonyms: Ins(1,4,5)P3)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

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CAS No.: 85166-31-0
Formula: C₆H₁₅O₁₅P₃
Molecular Weight:420.09

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Please store the product under the recommended conditions in the Certificate of Analysis.

D-myo-Inositol-1,4,5-triphosphate Chemical Structure

CAS No.: 85166-31-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
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Publications (1)
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Biological Activity

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	EC₅₀	329 nM Compound: Ins(1,4,5)	Effect on [Ca2+] efflux in rat hepatocytes Effect on [Ca2+] efflux in rat hepatocytes	[PMID: 10091701]
Hepatocyte	EC₅₀	90 nM Compound: 1[Ins(1,4,5)P3]	Concentration causing maximal effect on [Ca2+] release from the intracellular stores of permealized hepatocytes Concentration causing maximal effect on [Ca2+] release from the intracellular stores of permealized hepatocytes	[PMID: 11405648]
Hepatocyte	EC₅₀	0.08 nM Compound: 1	Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes with respect to compound 2 Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes with respect to compound 2	[PMID: 14584937]
Hepatocyte	EC₅₀	185 nM Compound: 1	Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes	[PMID: 14584937]
Hepatocyte	IC₅₀	200 nM Compound: 1 (Ins(1,4,5)P3)	Binding affinity against Ins(1,4,5)P3 receptor prepared from purified guinea pig hepatocytes Binding affinity against Ins(1,4,5)P3 receptor prepared from purified guinea pig hepatocytes	10.1016/0960-894X(95)00200-D
Lvec	EC₅₀	247 nM Compound: 1	Steady-State [Ca2+] Release from Saponin-Permeabilized Lvec Cell Lines Steady-State [Ca2+] Release from Saponin-Permeabilized Lvec Cell Lines	[PMID: 10354407]
NIH3T3	IC₅₀	300 nM Compound: 1 (Ins(1,4,5)P3)	Binding affinity against Ins(1,4,5)P3 receptor in swiss 3T3 cells Binding affinity against Ins(1,4,5)P3 receptor in swiss 3T3 cells	10.1016/0960-894X(95)00200-D
SH-SY5Y	IC₅₀	4.43 nM Compound: 1	The compound was tested for inhibitory activity against IInositol 1,4,5-trisphosphate receptor in SH-SY5Y cell line The compound was tested for inhibitory activity against IInositol 1,4,5-trisphosphate receptor in SH-SY5Y cell line	[PMID: 10354407]
SH-SY5Y	IC₅₀	52 nM Compound: D-chiro-Ins(1,3,4)P3	The compound was tested for inhibitory activity against Inositol 1,4,5-trisphosphate receptor in SH-SY5Y cell line The compound was tested for inhibitory activity against Inositol 1,4,5-trisphosphate receptor in SH-SY5Y cell line	[PMID: 10354407]
SH-SY5Y	EC₅₀	52.1 nM Compound: 1,4,5-IP3	Tested for [Ca2+] release in 45 [Ca2+] -preloaded SH-SY5Y cells using saponin Tested for [Ca2+] release in 45 [Ca2+] -preloaded SH-SY5Y cells using saponin	[PMID: 8411022]
SH-SY5Y	EC₅₀	51.6 nM Compound: 1,4,5-InsP3	Effective concentration required for Calcium release via the intracellular InsP3 receptor of SH-SY5Y cells Effective concentration required for Calcium release via the intracellular InsP3 receptor of SH-SY5Y cells	10.1016/0960-894X(95)00210-K
SH-SY5Y	EC₅₀	52 nM Compound: 1 {Ins (1,4,5)P3}	Compound was evaluated for its ability to mobilize calcium from [Ca(2+)]-preloaded SH-SY5Y cells permeabilised using saponin Compound was evaluated for its ability to mobilize calcium from [Ca(2+)]-preloaded SH-SY5Y cells permeabilised using saponin	10.1016/S0960-894X(00)80007-4

Chemical Information

CAS No. 85166-31-0
Molecular Weight 420.09
Formula C₆H₁₅O₁₅P₃
SMILES

O(P(=O)(O)O)[C@H]1[C@H](OP(=O)(O)O)[C@@H](O)[C@@H](O)[C@@H](OP(=O)(O)O)[C@@H]1O
Synonyms

Ins(1,4,5)P3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Asian J Androl

Participation of the inositol 1,4,5-trisphosphate-gated calcium channel in the zona pellucida- and progesterone-induced acrosome reaction and calcium influx in human spermatozoa. [Abstract]

2020 Mar-Apr;22(2):192-199. PMID: 31169139

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Bioz

Keywords

D-myo-Inositol-1,4,5-triphosphate

1 Cited Publications

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Biological Activity
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Chemical Information
Publications (1)
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D-myo-Inositol-1,4,5-triphosphate

Publications Citing Use of MedChemExpress (MCE) D-myo-Inositol-1,4,5-triphosphate

All Endogenous Metabolite Isoforms