Danoprevir sodium
Based on 20 publication(s) in Google Scholar
Danoprevir (sodium) (ITMN-191) is a compound used to inhibit hepatitis C virus infection.
For research use only. We do not sell to patients.
- CAS No.: 916826-48-7
- Formula: C35H46FN5NaO9S
- Molecular Weight:754.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Danoprevir sodium
More- Signal Transduct Target Ther. 2021 May 29;6(1):212. [Abstract]
- Cell Res. 2024 Jan;34(1):31-46. [Abstract]
- Nat Methods. 2018 Jul;15(7):519-522. [Abstract]
- Nat Commun. 2014 Oct 30:5:5352. [Abstract]
- Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):867-876. [Abstract]
- Avicenna J Phytomed. 2021 Jul-Aug;11(4):353-366. [Abstract]
- Fungal Biol. 2021 May;125(5):378-388. [Abstract]
- Virology. 2014 May:456-457:300-9. [Abstract]
- Boston University. 2025.
- bioRxiv. 2025 Aug 31:2025.08.26.672367. [Abstract]
- Patent. US12065501.
- University of Colorado Denver. 2024.
- bioRxiv. 2023 Mar 20:2023.03.20.533499. [Abstract]
- bioRxiv. 2023 Feb 27:2023.02.27.530290. [Abstract]
- Patent. US20210238569A1.
- bioRxiv. 2020 Apr.
- Patent. US20190010245A1.
- Patent. US20180346589A1.
- Patent. US20170233708A1.
- Seoul National University. 2016 Aug.
Customer Validation & Images
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 916826-48-7
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Molecular Weight 754.82
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Formula C35H46FN5NaO9S
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SMILES
O=S(NC([C@]1(C[C@@]1([H])/C=C/CCCCC[C@@H]2NC(OC(C)(C)C)=O)NC([C@@](C3)([H])N(C[C@@H]3OC(N4CC(C(F)=CC=C5)=C5C4)=O)C2=O)=O)=O)(C6CC6)=O.[Na]
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Synonyms
ITMN-191 sodium; R7227 sodium; RO5190591 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (20)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. [Abstract]2021 May 29;6(1):212. PMID: 34052830 -
Cell Res
Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells. [Abstract]2024 Jan;34(1):31-46. PMID: 38172533 -
Nat Methods
2018 Jul;15(7):519-522. PMID: 29967495 -
Nat Commun
A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. [Abstract]2014 Oct 30:5:5352. PMID: 25355134 -
Int J Radiat Oncol Biol Phys
Targeting Phosphatidylinositol 4-Kinase IIIα for Radiosensitization: A Potential Model of Drug Repositioning Using an Anti-Hepatitis C Viral Agent. [Abstract]2016 Nov 15;96(4):867-876. PMID: 27788957 -
Avicenna J Phytomed
Inhibitory activity of limonoids from Khaya grandifoliola C.DC (Meliaceae) against hepatitis C virus infection in vitro. [Abstract]2021 Jul-Aug;11(4):353-366. PMID: 34290967 -
Fungal Biol
The serine peptidase inhibitor N-ρ-tosyl-l-phenylalanine chloromethyl ketone (TPCK) affects the cell biology of Candida haemulonii species complex. [Abstract]2021 May;125(5):378-388. PMID: 33910679 -
Virology
Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors. [Abstract]2014 May:456-457:300-9. PMID: 24889249
Danoprevir sodium purchased from MedChemExpress. Usage Cited in: Virology. 2014 May:456-457:300-9. [Abstract]
Jurkat cells are transfected with plasmids expressing (A) HCV NS3/4A or (B) HPgV NS3/4AB-HA. Telaprevir, Boceprevir, and Danoprevir are added at concentrations of 100 µM, 16.6 µM, 2.7 µM, or 0 µM in 0.1% DMSO. Lysates are harvested after 24 h and resolved by immunoblots probed with anti-HCV NS3 (A) or anti-HA (B). The position of HCV NS3/4A (~75kDa), HCV NS3 (~73kDa), NS3/4AB-HA, and NS4B-HA (~30kDa) are indicated. Molecular markers are on the right.
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bioRxiv
Replating induces mTOR-dependent rescue of protein synthesis in Charcot-Marie-Tooth diseased neurons. [Abstract]2025 Aug 31:2025.08.26.672367. PMID: 40909707 -
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bioRxiv
Orthogonal inducible control of Cas13 circuits enables programmable RNA regulation in mammalian cells. [Abstract]2023 Mar 20:2023.03.20.533499. PMID: 36993327 -
bioRxiv
Controlled protein activities with viral proteases, antiviral peptides, and antiviral drugs. [Abstract]2023 Feb 27:2023.02.27.530290. PMID: 36909459 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Danoprevir sodium Related Classifications
HY-10239 Related Classifications
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