Danoprevir sodium
Based on 20 publication(s) in Google Scholar
Danoprevir (sodium) (ITMN-191) is a compound used to inhibit hepatitis C virus infection.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 916826-48-7
- Fòrmula: C35H46FN5NaO9S
- Peso molecular:754.82
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Danoprevir sodium
More- Signal Transduct Target Ther. 2021 May 29;6(1):212. [Abstract]
- Cell Res. 2024 Jan;34(1):31-46. [Abstract]
- Nat Methods. 2018 Jul;15(7):519-522. [Abstract]
- Nat Commun. 2014 Oct 30:5:5352. [Abstract]
- Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):867-876. [Abstract]
- Avicenna J Phytomed. 2021 Jul-Aug;11(4):353-366. [Abstract]
- Fungal Biol. 2021 May;125(5):378-388. [Abstract]
- Virology. 2014 May:456-457:300-9. [Abstract]
- Boston University. 2025.
- bioRxiv. 2025 Aug 31:2025.08.26.672367. [Abstract]
- Patent. US12065501.
- University of Colorado Denver. 2024.
- bioRxiv. 2023 Mar 20:2023.03.20.533499. [Abstract]
- bioRxiv. 2023 Feb 27:2023.02.27.530290. [Abstract]
- Patent. US20210238569A1.
- bioRxiv. 2020 Apr.
- Patent. US20190010245A1.
- Patent. US20180346589A1.
- Patent. US20170233708A1.
- Seoul National University. 2016 Aug.
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Actividad biológica
Descripciòn
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 916826-48-7
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Peso molecular 754.82
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Fòrmula C35H46FN5NaO9S
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SMILES
O=S(NC([C@]1(C[C@@]1([H])/C=C/CCCCC[C@@H]2NC(OC(C)(C)C)=O)NC([C@@](C3)([H])N(C[C@@H]3OC(N4CC(C(F)=CC=C5)=C5C4)=O)C2=O)=O)=O)(C6CC6)=O.[Na]
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Synonyms
ITMN-191 sodium; R7227 sodium; RO5190591 sodium
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (20)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. [Abstract]2021 May 29;6(1):212. PMID: 34052830 -
Cell Res
Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells. [Abstract]2024 Jan;34(1):31-46. PMID: 38172533 -
Nat Methods
2018 Jul;15(7):519-522. PMID: 29967495 -
Nat Commun
A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. [Abstract]2014 Oct 30:5:5352. PMID: 25355134 -
Int J Radiat Oncol Biol Phys
Targeting Phosphatidylinositol 4-Kinase IIIα for Radiosensitization: A Potential Model of Drug Repositioning Using an Anti-Hepatitis C Viral Agent. [Abstract]2016 Nov 15;96(4):867-876. PMID: 27788957 -
Avicenna J Phytomed
Inhibitory activity of limonoids from Khaya grandifoliola C.DC (Meliaceae) against hepatitis C virus infection in vitro. [Abstract]2021 Jul-Aug;11(4):353-366. PMID: 34290967 -
Fungal Biol
The serine peptidase inhibitor N-ρ-tosyl-l-phenylalanine chloromethyl ketone (TPCK) affects the cell biology of Candida haemulonii species complex. [Abstract]2021 May;125(5):378-388. PMID: 33910679 -
Virology
Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors. [Abstract]2014 May:456-457:300-9. PMID: 24889249
Danoprevir sodium purchased from MedChemExpress. Usage Cited in: Virology. 2014 May:456-457:300-9. [Abstract]
Jurkat cells are transfected with plasmids expressing (A) HCV NS3/4A or (B) HPgV NS3/4AB-HA. Telaprevir, Boceprevir, and Danoprevir are added at concentrations of 100 µM, 16.6 µM, 2.7 µM, or 0 µM in 0.1% DMSO. Lysates are harvested after 24 h and resolved by immunoblots probed with anti-HCV NS3 (A) or anti-HA (B). The position of HCV NS3/4A (~75kDa), HCV NS3 (~73kDa), NS3/4AB-HA, and NS4B-HA (~30kDa) are indicated. Molecular markers are on the right.
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bioRxiv
Replating induces mTOR-dependent rescue of protein synthesis in Charcot-Marie-Tooth diseased neurons. [Abstract]2025 Aug 31:2025.08.26.672367. PMID: 40909707 -
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bioRxiv
Orthogonal inducible control of Cas13 circuits enables programmable RNA regulation in mammalian cells. [Abstract]2023 Mar 20:2023.03.20.533499. PMID: 36993327 -
bioRxiv
Controlled protein activities with viral proteases, antiviral peptides, and antiviral drugs. [Abstract]2023 Feb 27:2023.02.27.530290. PMID: 36909459 -
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Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Danoprevir sodium Related Classifications
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