DBCO-PEG8-NHS ester
Based on 1 Customer Validation
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG8-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 98.34%
- CAS No.: 2553412-88-5
- Formula: C42H55N3O14
- Molecular Weight:825.90
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
|
PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2553412-88-5
-
Appearance Oil
-
Molecular Weight 825.90
-
Formula C42H55N3O14
-
Color Light yellow to yellow
-
SMILES
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 200 mg/mL (242.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2108 mL | 6.0540 mL | 12.1080 mL | 30.2700 mL |
| 5 mM | 0.2422 mL | 1.2108 mL | 2.4216 mL | 6.0540 mL | |
| 10 mM | 0.1211 mL | 0.6054 mL | 1.2108 mL | 3.0270 mL | |
| 15 mM | 0.0807 mL | 0.4036 mL | 0.8072 mL | 2.0180 mL | |
| 20 mM | 0.0605 mL | 0.3027 mL | 0.6054 mL | 1.5135 mL | |
| 25 mM | 0.0484 mL | 0.2422 mL | 0.4843 mL | 1.2108 mL | |
| 30 mM | 0.0404 mL | 0.2018 mL | 0.4036 mL | 1.0090 mL | |
| 40 mM | 0.0303 mL | 0.1514 mL | 0.3027 mL | 0.7568 mL | |
| 50 mM | 0.0242 mL | 0.1211 mL | 0.2422 mL | 0.6054 mL | |
| 60 mM | 0.0202 mL | 0.1009 mL | 0.2018 mL | 0.5045 mL | |
| 80 mM | 0.0151 mL | 0.0757 mL | 0.1514 mL | 0.3784 mL | |
| 100 mM | 0.0121 mL | 0.0605 mL | 0.1211 mL | 0.3027 mL |
Powered by Bioz