DBCO2-SS2-PEG24
DBCO2-SS2-PEG24 is a bivalent shielding agent containing dibenzocyclooctyne (DBCO) and PEG24 domains, synthesized for copper-free click reaction-mediated postmodification of azide-bearing siRNA lipo-polyplexes.DBCO2-SS2-PEG24 can be used for the research of cervical carcinoma, hepatocellular carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 2304536-81-8
- Formula: C113H173N9O35S4
- Molecular Weight:2345.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DBCO2-SS2-PEG24 (0.25-1 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes maintain stable spherical morphology, provide effective charge shielding, exhibit good serum stability, and mediate moderate gene silencing in EGFR-overexpressing KB/eGFPLuc and Huh7/eGFPLuc cells[1].
DBCO2-SS2-PEG24 (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes exhibit lower cellular internalization efficiency in EGFR-overexpressing KB and Huh7 cells compared to GE11-targeted DBCO-modified polyplexes[1].
DBCO2-SS2-PEG24 (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes mediate moderate EG5 gene silencing and antitumoral activity in EGFR-overexpressing KB and Huh7 cells, with lower efficacy than GE11-targeted DBCO-modified polyplexes[1].
DBCO2-SS2-PEG24 (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes induce moderate EG5 silencing-related mitotic arrest and apoptosis in EGFR-overexpressing KB and Huh7 cells, with lower potency than GE11-targeted DBCO-modified polyplexes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2304536-81-8
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Molecular Weight 2345.88
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Formula C113H173N9O35S4
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SMILES
O=C(CCC(NCCSSCCCNC(CCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)CCCCNC(CCC(NCCCSSCCNC(CCC(N1CC2=CC=CC=C2C#CC3=CC=CC=C31)=O)=O)=O)=O)=O)=O)=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DBCO2-SS2-PEG24 Related Classifications
HY-185694 Related Classifications
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