Art. -Nr.: HY-N1970

5,7-Dihydroxychromone

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection.

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Reinheit: 99.94%
CAS. Nr.: 31721-94-5
Formel: C₉H₆O₄
Molecular Weight:178.14

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

5,7-Dihydroxychromone Chemical Structure

CAS. Nr.: 31721-94-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Caspase-3

Caspase-9

PARP

Alle Caspase Isoform-spezifische Produkte anzeigen :

Alle PARP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	EC₅₀	1.9 μM Compound: 24	Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 6-OHDA-induced cell death measured after 24 hrs by MTT assay Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 6-OHDA-induced cell death measured after 24 hrs by MTT assay	[PMID: 27420919]

In Vitro

5,7-Dihydroxychromone (DHC) (0.4-10 μM; 24 h pre-incubation) dose-dependently protects SH-SY5Y cells from 6-OHDA (HY-B1081)-induced cell death, and this effect is eliminated by Nrf2 siRNA transfection (48 h pre-transfection)^[1].
5,7-Dihydroxychromone (DHC) (0.4-10 μM; 24 h pre-incubation) dose-dependently inhibits 6-OHDA-induced intracellular ROS generation in SH-SY5Y cells, with 10 μM DHC reducing ROS levels to ~2-fold above the vehicle control, and this effect is eliminated by Nrf2 siRNA transfection (48 h pre-transfection)^[1].
5,7-Dihydroxychromone (DHC) (2 μM; 1-12 h) time- and (0.08-10 μM; 6 h) dose-dependently induces Nrf2 nuclear translocation in SH-SY5Y cells, with 2 μM DHC producing a peak effect at 6 h and 0.08 to 10 μM DHC increasing nuclear Nrf2 levels in a dose-dependent manner at 6 h^[1].
5,7-Dihydroxychromone (DHC) (2 μM; 1-12 h) increases Nrf2/ARE binding activity in SH-SY5Y cells, with 2 μM DHC producing maximum binding activity at 12 h^[1].
5,7-Dihydroxychromone (DHC) (2 μM; 1-24 h) time- and (0.08-10 μM; 24 h) dose-dependently increases protein expression of the Nrf2-dependent antioxidant enzymes HO-1, NQO1, and GCLc in SH-SY5Y cells, and this effect is eliminated by Nrf2 siRNA transfection (48 h pre-transfection)^[1].
5,7-Dihydroxychromone (DHC) (0.08-10 μM; 24 h pre-incubation) dose-dependently inhibits 6-OHDA-induced expression of cleaved caspase-3, cleaved caspase-9, and cleaved PARP in SH-SY5Y cells^[1].
5,7-Dihydroxychromone (1-10 μg/mL; 9 d) potently induces differentiation of mouse 3T3-L1 preadipocytes in a concentration-dependent manner, with 10 μg/mL driving differentiation to 185% of control^[2].
5,7-Dihydroxychromone (1-10 μg/mL) increases PPARγ and LXRα mRNA expression in mouse 3T3-L1 preadipocytes in vitro in a concentration-dependent manner, with 10 μg/mL driving 30-fold and 22-fold increases respectively^[2].
5,7-Dihydroxychromone (5-100 μM; until maximum radial growth reached) inhibits radial growth of Rhizoctonia solani (IC₅₀ = 18 μM) and Sclerotium rolfsii (IC₅₀ = 26 μM), with fungicidal activity at 100 μM^[3].
5,7-Dihydroxychromone (10^-7-10^-3 M; 48 hr) inhibits radicle elongation of velvetleaf (IC₅₀ = 30 μM), corn (cv. DeKalb IL 645-786; IC₅₀ = 50 μM), peanut (cv. Red Tennessee; IC₅₀ = 65 μM), and wheat (cv. Cardinal; IC₅₀ = 200 μM) after 48 hr of incubation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

0.4 μM, 2 μM, 10 μM; 10 μM (with Nrf2 siRNA pre-transfection)
Incubation Time:

24 h (pre-incubation); 48 h (Nrf2 siRNA pre-transfection)
Result:

Reduced 6-OHDA-induced cell death in a dose-dependent manner.
Decreased the percentage of PI-positive dead cells from 44.5% (6-OHDA-only group) to 13.8% at 10 μM.
Abolished the protective effect when Nrf2 siRNA was transfected, increasing the percentage of PI-positive cells to 50.1% in the 10 μM DHC + 6-OHDA group.

Western Blot Analysis^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

2 μM (time-course); 0.08-10 μM (dose-response)
Incubation Time:

1-12 h (2 μM); 6 h (0.08-10 μM)
Result:

Increased nuclear Nrf2 levels in a time-dependent manner at 2 μM, with a peak effect at 6 h.
Increased nuclear Nrf2 levels in a dose-dependent manner after 6 h treatment with 0.08-10 μM.
Showed increased nuclear Nrf2 fluorescence via immunocytochemical staining.

Western Blot Analysis^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

0.08-10 μM
Incubation Time:

24 h (pre-incubation)
Result:

Inhibited 6-OHDA-induced expression of cleaved caspase-3, cleaved caspase-9, and cleaved PARP in a dose-dependent manner.

In Vivo

5,7-dihydroxychromone, delivered as an active component of Daphniphyllum macropodum fruit extract
(DME), dose-dependently reduces serum glucose, total cholesterol, and triacylglycerol levels, and increases liver PPARγ and LXRα mRNA expression, in streptozotocin-/high-fat diet-induced type 2 diabetic ICR mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 31721-94-5
Appearance Solid
Molecular Weight 178.14
Formel C₉H₆O₄
Color White to light yellow
SMILES

O=C1C=COC2=CC(O)=CC(O)=C12
Structure Classification
- Flavonoids
- Isoflavones
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Planta Medica International Open

2022; 9(01): e108-e115.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (561.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.6136 mL

28.0678 mL

56.1356 mL

5 mM

1.1227 mL

5.6136 mL

11.2271 mL

10 mM

0.5614 mL

2.8068 mL

5.6136 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kim DW, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015;130:25-30. [Content Brief]

[2]. Koo HJ, et al. Anti-diabetic properties of Daphniphyllum macropodum fruit and its active compound. Biosci Biotechnol Biochem. 2014;78(8):1392-401. [Content Brief]

[3]. Vaughn SF, et al. Phytotoxic and antimicrobial activity of 5,7-dihydroxychromone from peanut shells. J Chem Ecol. 1995;21(2):107-115. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.6136 mL	28.0678 mL	56.1356 mL	140.3391 mL
	5 mM	1.1227 mL	5.6136 mL	11.2271 mL	28.0678 mL
	10 mM	0.5614 mL	2.8068 mL	5.6136 mL	14.0339 mL
	15 mM	0.3742 mL	1.8712 mL	3.7424 mL	9.3559 mL
	20 mM	0.2807 mL	1.4034 mL	2.8068 mL	7.0170 mL
	25 mM	0.2245 mL	1.1227 mL	2.2454 mL	5.6136 mL
	30 mM	0.1871 mL	0.9356 mL	1.8712 mL	4.6780 mL
	40 mM	0.1403 mL	0.7017 mL	1.4034 mL	3.5085 mL
	50 mM	0.1123 mL	0.5614 mL	1.1227 mL	2.8068 mL
	60 mM	0.0936 mL	0.4678 mL	0.9356 mL	2.3390 mL
	80 mM	0.0702 mL	0.3508 mL	0.7017 mL	1.7542 mL
	100 mM	0.0561 mL	0.2807 mL	0.5614 mL	1.4034 mL

Keywords

5,7-Dihydroxychromone

2 Cited Publications

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5,7-Dihydroxychromone

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Publications Citing Use of MedChemExpress (MCE) 5,7-Dihydroxychromone

Alle Caspase Isoform-spezifische Produkte anzeigen

Alle PARP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

5,7-Dihydroxychromone Related Classifications

HY-N1970 Related Classifications