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Art. -Nr.: HY-147539

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Antitumor agent-65

Antitumor agent-65 (Compound 5) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-65 has the potential for the research of cancer diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2456288-82-5
Formel: C₁₈H₁₇NO₁₀
Molecular Weight:407.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antitumor agent-65 Chemical Structure

CAS. Nr.: 2456288-82-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Antitumor agent-65 (Compound 5) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-65 has the potential for the research of cancer diseases^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.64 μM Compound: 5	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
HeLa	IC₅₀	4.65 μM Compound: 5	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
HL-60	IC₅₀	1.11 μM Compound: 5	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
Jurkat	IC₅₀	7.45 μM Compound: 5	Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
K562	IC₅₀	7.64 μM Compound: 5	Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MCF7	IC₅₀	5.32 μM Compound: 5	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MDA-MB-231	IC₅₀	4.12 μM Compound: 5	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
MRC5	IC₅₀	>100 μM Compound: 5	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 6 days by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]
Raji	IC₅₀	18.54 μM Compound: 5	Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 6 days by MTT assay Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 6 days by MTT assay	[PMID: 32653698]

Chemical Information

CAS. Nr. 2456288-82-5
Molecular Weight 407.33
Formel C₁₈H₁₇NO₁₀
SMILES

CC(O[C@@H]1C=CC(O[C@@H]1[C@H](OC(C)=O)COC(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Benedeković G, et al. Synthesis, antiproliferative activity and SAR analysis of (-)-cleistenolide and analogues. Eur J Med Chem. 2020 Sep 15;202:112597. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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