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Art. -Nr.: HY-P990036

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Biologically Validated

Dazukibart

Name: Dazukibart
Brand: MedChemExpress
SKU: HY-P990036
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: PF-06823859)

Kundenbewertung

Based on 1 Customer Validation

Dazukibart (PF‑06823859) is a humanized IgG1 monoclonal antibody targeting IFN‑β that binds to and neutralizes IFN-β. Dazukibart can be used in research on autoimmune inflammatory diseases such as dermatomyositis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.9%
CAS. Nr.: 2639474-65-8
Molecular Weight:145.36 kDa

Speicherung:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Dazukibart Chemical Structure

CAS. Nr.: 2639474-65-8

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IFNB1

In Vitro

Innate Immunity

Dazukibart neutralizes IFN-β and inhibits downstream type I interferon-dependent inflammatory signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

3456 [NCBI]

Accession

P01574

Conjugated

Unconjugated

Reconstitution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Animal-Free IFN-beta Protein, Human (His, HY-P700090AF) can bind Dazukibart. The EC₅₀ for this effect is 11.01 ng/mL.

Chemical Information

CAS. Nr. 2639474-65-8
Appearance Liquid
Molecular Weight 145.36 kDa
Color Colorless to light yellow
SMILES

[Dazukibart]
Synonyms

PF-06823859
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Sevim E, et al. A comprehensive review of dermatomyositis treatments - from rediscovered classics to promising horizons. Expert review of clinical immunology. 2024 Feb;20(2):197-209.

[2]. Kaewin S, et al. Inhibition of the type I interferon receptor pathway protects against muscle weakness induced by dermatomyositis serum. Annals of the rheumatic diseases. 2026 Jun;85(6):1180-1190. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Dazukibart

HOLO Human Interleukin-2 (IL-2) Detection Kit

Cell-ATP Viability Detection Kit

Protein A Agarose

Bradford Protein Assay Kit

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)