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PDLIM5 - PDZ and LIM domain 5 Gene

Also Known as L9; ENH; LIM; ENH1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10611

About PDLIM5

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:94,451,942-94,668,223 (from NCBI)

This gene has 23 transcripts (splice variants), 281 orthologues and 7 paralogues. Broad expression in heart (RPKM 70.2), prostate (RPKM 31.5) and 23 other tissues.

Summary

This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

PDLIM5 Products (9)

mRNA	Protein	Name
NM_001011513.4	NP_001011513.4	PDZ and LIM domain protein 5 isoform b
NM_001011515.3	NP_001011515.1	PDZ and LIM domain protein 5 isoform d
NM_001011516.3	NP_001011516.1	PDZ and LIM domain protein 5 isoform e
NM_001256425.2	NP_001243354.2	PDZ and LIM domain protein 5 isoform c
NM_001256426.2	NP_001243355.2	PDZ and LIM domain protein 5 isoform f
NM_001256427.2	NP_001243356.2	PDZ and LIM domain protein 5 isoform g
NM_001256428.2	NP_001243357.2	PDZ and LIM domain protein 5 isoform h
NM_001256429.2	NP_001243358.1	PDZ and LIM domain protein 5 isoform i
NM_006457.5	NP_006448.5	PDZ and LIM domain protein 5 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16549780	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDLIM5 Protein Structure

PDZ

LIM

0
100
200
300
400
500
596 a.a.

Protein Preferred Names	Protein Names
PDZ and LIM domain protein 5	enigma homolog

PDLIM5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PDLIM5	Q96HC4	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
Intra	PDLIM5	Q96HC4	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	PDLIM5	Q96HC4	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	PDLIM5	Q96HC4	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	PDLIM5	Q96HC4	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	PDLIM5	Q96HC4	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	PDLIM5	Q96HC4	ZYX	Homo sapiens	Q15942	Validated Y2H	25416956
Intra	PDLIM5	Q96HC4	ID2	Homo sapiens	Q02363	Anti Tag CoIP	16549780
Intra	PDLIM5	Q96HC4	ID2	Homo sapiens	Q02363	Anti Bait CoIP	16549780
Intra	PDLIM5	Q96HC4	ID2	Homo sapiens	Q02363	Pull Down	16549780
Intra	PDLIM5	Q96HC4	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	PDLIM5	Q96HC4	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	PDLIM5	Q96HC4	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	PDLIM5	Q96HC4	COIL	Homo sapiens	P38432	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nail-Patella Syndrome	Turner-Kieser Syndrome Onychoosteodysplasia Fong Disease NPS Hereditary Onycho-Osteodysplasia Nps1 Hereditary Onychoostedysplasia Iliac Horn Syndrome Nail Patella Syndrome Turner-Kiser Syndrome Arthro-Onychodysplasia Nps 1 Osteo-Onychodysplasia Hereditary Osteo-Onychodysplasia Osterreicher Syndrome Pelvic Horn Syndrome Österreicher-Turner Syndrome Nps - [Nail-Patella Syndrome] Hood - [Hereditary Onycho-Osteodysplasia] Syndrome
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Lissencephaly 3	LIS3 Lissencephaly Due To Tuba1a Mutation Lissencephaly Type 3 Lissencephaly, Type 3
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10283	PDLIM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21904	Pdlim5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDLIM5	VGNC	VGNC:32711
Felis catus	PDLIM5	VGNC	VGNC:64092
Macaca mulatta	PDLIM5	VGNC	VGNC:75816
Canis familiaris	PDLIM5	VGNC	VGNC:44387
Rattus norvegicus	PDLIM5	RGD	RGD:621076
Mus musculus	PDLIM5	MGD	MGI:1927489
Others	PDLIM5	NCBI