RPSA - ribosomal protein SA Gene

Also Known as SA; LBP; LRP; p40; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3921

About RPSA

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,406,720-39,412,542 (from NCBI)

This gene has 20 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 792.7), lymph node (RPKM 583.0) and 25 other tissues.

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the Integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung Cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in Cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RPSA Products (2)

mRNA	Protein	Name
NM_001304288.2	NP_001291217.1	40S ribosomal protein SA isoform 2
NM_002295.6	NP_002286.2	40S ribosomal protein SA isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	38114488	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables ribosome binding	IPI IPI: Inferred from physical interaction	10079194	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	38114488	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16263087	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	38114488	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16263087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPSA Protein Structure

Ribosomal_S2

0
100
200
295 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein SA	37 kDa laminin receptor

RPSA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RPSA	P08865	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
Intra	RPSA	P08865	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	RPSA	P08865	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	RPSA	P08865	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	RPSA	P08865	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	RPSA	P08865	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	RPSA	P08865	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	RPSA	P08865	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
Intra	RPSA	P08865	KARS1	Homo sapiens	Q15046	Anti Tag CoIP	24212136
Intra	RPSA	P08865	KARS1	Homo sapiens	Q15046	Pull Down	24212136
Intra	RPSA	P08865	KARS1	Homo sapiens	Q15046	NMR	24983501
Intra	RPSA	P08865	KARS1	Homo sapiens	Q15046	GMS	24983501
Intra	RPSA	P08865	KARS1	Homo sapiens	Q15046	Y2H	24212136
Intra	RPSA	P08865	RPS21	Homo sapiens	P63220	Anti Tag CoIP	33961781
Intra	RPSA	P08865	RPS21	Homo sapiens	P63220	Anti Tag CoIP	28514442
Intra	RPSA	P08865	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	RPSA	P08865	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	RPSA	P08865	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RPSA	P08865	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	RPSA	P08865	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RPSA	P08865	GAB2	Homo sapiens	Q9UQC2	Validated Y2H	32814053
Intra	RPSA	P08865	GAB2	Homo sapiens	Q9UQC2	Y2H Array	32814053
Intra	RPSA	P08865	GAB2	Homo sapiens	Q9UQC2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

RPSA Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82214	67kDa Laminin Receptor Antibody (YA1959)	WB, IP	Human, Mouse, Rat
HY-P82214A	67kDa Laminin Receptor Antibody (YA1959)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Asplenia, Isolated Congenital	ICAS Splenic Hypoplasia Familial Isolated Congenital Asplenia Hyposplenia, Isolated Congenital Asplenia, Familial Isolated Congenital Asplenia Congenital Hypoplasia Of Spleen Hypoplasia Of Spleen Spenlic Hypoplasia Congenital Isolated Hyposplenia Familial Asplenia
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian
Scrapie
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Flying Phobia	Aerophobia
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Chronic Wasting Disease	Wasting Disease, Chronic
Gummatous Syphilis
Early Congenital Syphilis
Oral Mucosa Leukoplakia	Leukoplakia, Oral Leukoplakia Of Buccal Mucosa
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9	Arrhythmogenic Right Ventricular Dysplasia 9 ARVD9 Arrhythmogenic Right Ventricular Cardiomyopathy 9 Arvc9 Familial Arrhythmogenic Right Ventricular Dysplasia 9 Dysplasia, Arrhythmogenic Right Ventricular, Type 9
Meningovascular Neurosyphilis
Primary Syphilis	Early Symptomatic Syphilis Early Syphilis, Symptomatic Symptomatic Early Syphilis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Right Atrial Isomerism	Ivemark Syndrome Asplenia With Cardiovascular Anomalies RAI Asplenia Syndrome Asplenia Right Isomerism Splenic Agenesis Syndrome Bilateral Right-Sidedness Sequence Right Sided Atrial Isomerism Isomerism Of Right Atrial Appendage Heterotaxy, Visceroatrial, Autosomal Recessive Polyasplenia Vah, Autosomal Recessive Atrial Isomerism, Right Congenital Absence Of Spleen Bilateral Right-Sidedness
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-146446	PXYC1	Inhibitor	99.50%	Unkown
HY-146447	PXYC13	Inhibitor	/	Unkown
HY-146448	PXYD3	Inhibitor	/	Unkown
HY-146449	PXYD4	Inhibitor	/	Unkown
HY-146450	PXYC2	Inhibitor	/	Unkown
HY-146451	PXYC12	Inhibitor	/	Unkown
HY-RS12272	RPSA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22312	Rpsa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28834	Rpsa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPSA	VGNC	VGNC:50207
Mus musculus	RPSA	MGD	MGI:105381
Rattus norvegicus	RPSA	RGD	RGD:71026