DAGLA - diacylglycerol lipase alpha Gene

Also Known as NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 747

About DAGLA

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,680,391-61,747,001 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 3 paralogues. Broad expression in brain (RPKM 6.7), colon (RPKM 2.0) and 20 other tissues.

Summary

This gene encodes a diacylglycerol Lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]

DAGLA Products (1)

mRNA Protein Name
NM_006133.3 NP_006124.1 diacylglycerol lipase-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
23502535 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
14610053 GOA
involved in diacylglycerol catabolic process IDA
IDA: Inferred from direct assay
14610053 GOA
involved in diacylglycerol catabolic process IMP
IMP: Inferred from mutant phenotype
23502535 GOA
involved in retrograde trans-synaptic signaling by endocannabinoid IMP
IMP: Inferred from mutant phenotype
23502535 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in dendrite membrane IDA
IDA: Inferred from direct assay
27595600 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
27595600 GOA
located in postsynaptic density membrane IDA
IDA: Inferred from direct assay
27595600 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAGLA Protein Structure

Lipase_3

Lipase_3: Lipase (class 3) (394 - 529)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1042 a.a.
Protein Preferred Names Protein Names

diacylglycerol lipase-alpha

  • DAGL-alpha

DAGLA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DAGLA Q9Y4D2 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
DAGLA Q9Y4D2 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
DAGLA Q9Y4D2 UPK1B Homo sapiens O75841
Y2H Array
32296183
Intra
DAGLA Q9Y4D2 UPK1B Homo sapiens O75841
Y2H Prey Pooling
32296183
Intra
DAGLA Q9Y4D2 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
DAGLA Q9Y4D2 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 20

  • Spinocerebellar Ataxia Type 20

  • SCA20

  • Spinocerebellar Ataxia With Dysphonia

  • Spinocerebellar Ataxia With Spasmodic Cough

  • Chromosome 11q12 Duplication Syndrome, 260-Kb

  • Chromosome 11q12 Duplication Syndrome 260-Kb
Spasmodic Dysphonia

  • Adductor Spasmodic Dysphonia

  • Laryngeal Dystonia

  • Spastic Dysphonia

  • Abductor Spasmodic Dysphonia

  • Laryngeal Dyskinesia

  • Mixed Spasmodic Dysphonia

  • Abductor Spastic Dysphonia

  • Adductor Spastic Dysphonia
Cannabis Abuse

  • Marijuana Abuse
Cannabis Dependence

  • Marijuana Abuse

  • Cannabinoid Addiction

  • Cannabinoid Dependence

  • Cannabis Addiction
Hallucinogen Dependence

  • Hallucinogen Addiction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P4406 Abz-AGLA-Nba 99.71% Unkown
HY-P4406A Abz-AGLA-Nba TFA 99.64% Unkown
HY-RS03520 DAGLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DAGLA MGD MGI:2677061
Bos taurus DAGLA VGNC VGNC:27872
Canis familiaris DAGLA VGNC VGNC:39764
Rattus norvegicus DAGLA RGD RGD:1359461
Felis catus DAGLA VGNC VGNC:61332
Macaca mulatta DAGLA VGNC VGNC:107444
Others DAGLA NCBI