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Art. -Nr.: HY-182688

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ITYR-DBRMD

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression.

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CAS. Nr.: 1809339-61-4
Formel: C₁₃H₇Br₂I₂NO₅
Molecular Weight:670.82

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ITYR-DBRMD Chemical Structure

CAS. Nr.: 1809339-61-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression^[1].

In Vitro

ITYR-DBRMD (Compouund 5) (0.5 μM; 48 h) reduces cell viability in OVCAR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

OVCAR3 cells
Concentration:

0.5 μM
Incubation Time:

48 h
Result:

Reduced cell numbers by microscopy.

In Vivo

ITYR-DBRMD (Compound 5) (5 mg/kg; i.c.v.; continuous infusion via osmotic minipump) reduces the latency to feed in the novelty suppressed feeding test in BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 8 weeks old)^[1]
Dosage:

5 mg/kg
Administration:

i.c.v.; continuous infusion via osmotic minipump
Result:

Reduced the latency to feed in the novelty suppressed feeding test.

Chemical Information

CAS. Nr. 1809339-61-4
Molecular Weight 670.82
Formel C₁₃H₇Br₂I₂NO₅
SMILES

O=C(C(CC1=CC(I)=C(C(I)=C1)O)N2C(C(Br)=C(C2=O)Br)=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bernard Lerer, et al. Type iii deiodinase inhibitors and uses thereof. WO2015140792. 2016-09-16

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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