Cyclen
Based on 1 Customer Validation
Cyclen is a macrocyclic tetraamine chelating agent. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li+/Mg2+ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li+ ions[1][2].
For research use only. We do not sell to patients.
- Purity : 99.97%
- CAS No.: 294-90-6
- Formula: C8H20N4
- Molecular Weight:172.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W007656R
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
5 μM
Compound: 8
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Cytotoxicity against HEK cells
Cytotoxicity against HEK cells
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[PMID: 18313921] |
In Vitro
Cyclen binds dehydrated Li+ with an adsorption energy of -75.0 kJ/mol, forming a stable complex due to a well-matched molecular cavity size[2].
Cyclen in PEI/Cyclen-TMC composite membrane reduces the Mg2+/Li+ mass ratio of simulated salt lake brine from 40 to 0.3 over three nanofiltration stages, achieving a 45.5% Li+ recovery rate and producing Li2CO3 with 93% purity after precipitation and filtration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 294-90-6
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Appearance Solid
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Molecular Weight 172.28
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Formula C8H20N4
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Color White to off-white
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SMILES
C1CNCCNCCNCCN1
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (290.23 mM; Need ultrasonic)
DMSO : 1.85 mg/mL (10.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (786 KB)
- English - EN (786 KB)
- Français - FR (786 KB)
- Deutsch - DE (786 KB)
- Norwegian - NO (786 KB)
- Español - ES (786 KB)
- Swedish - SV (786 KB)
- Italian - IT (786 KB)
- Korean - KR (786 KB)
- Portuguese - PT (786 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.8045 mL | 29.0225 mL | 58.0450 mL | 145.1126 mL |
| 5 mM | 1.1609 mL | 5.8045 mL | 11.6090 mL | 29.0225 mL | |
| 10 mM | 0.5805 mL | 2.9023 mL | 5.8045 mL | 14.5113 mL | |
| H2O | 15 mM | 0.3870 mL | 1.9348 mL | 3.8697 mL | 9.6742 mL |
| 20 mM | 0.2902 mL | 1.4511 mL | 2.9023 mL | 7.2556 mL | |
| 25 mM | 0.2322 mL | 1.1609 mL | 2.3218 mL | 5.8045 mL | |
| 30 mM | 0.1935 mL | 0.9674 mL | 1.9348 mL | 4.8371 mL | |
| 40 mM | 0.1451 mL | 0.7256 mL | 1.4511 mL | 3.6278 mL | |
| 50 mM | 0.1161 mL | 0.5805 mL | 1.1609 mL | 2.9023 mL | |
| 60 mM | 0.0967 mL | 0.4837 mL | 0.9674 mL | 2.4185 mL | |
| 80 mM | 0.0726 mL | 0.3628 mL | 0.7256 mL | 1.8139 mL | |
| 100 mM | 0.0580 mL | 0.2902 mL | 0.5805 mL | 1.4511 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cyclen Related Classifications
HY-W007656 Related Classifications
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