AF3485
AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
For research use only. We do not sell to patients.
- CAS No.: 1195786-61-8
- Formula: C22H17F3N2O2
- Molecular Weight:398.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1195786-61-8
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Molecular Weight 398.38
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Formula C22H17F3N2O2
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SMILES
OCCN(C1=C2C=C(C=C1)NC(C3=CC=CC=C3C(F)(F)F)=O)C4=C2C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AF3485 Related Classifications
HY-118184 Related Classifications
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