Apoptosis inducer 63
Apoptosis inducer 63 is an Apoptosis inducer. Apoptosis inducer 63 induces apoptosis and interferes with cell cycle progression through G2/M phase arrest and subsequent G1 phase accumulation. Apoptosis inducer 63 exhibits anticancer activity against colorectal cancer, lung cancer, and epithelioid carcinoma. Apoptosis inducer 63 can be used for research on colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 872984-72-0
- Formula: C23H21N5O4
- Molecular Weight:431.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | CC50 |
3.71 μM
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Cytotoxicity against human epidermoid carcinoma A-431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Cytotoxicity against human epidermoid carcinoma A-431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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42570380 |
| BJ | CC50 |
11.58 μM
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Cytotoxicity against normal human epidermoid fibroblast BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Cytotoxicity against normal human epidermoid fibroblast BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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42570380 |
| A549 | CC50 |
9.21 μM
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Cytotoxicity against human lung carcinoma A-549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Cytotoxicity against human lung carcinoma A-549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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42570380 |
| NCI-H1299 | CC50 |
10.36 μM
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Cytotoxicity against human p53-deficient lung carcinoma NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Cytotoxicity against human p53-deficient lung carcinoma NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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42570380 |
| MRC5 | CC50 |
10.79 μM
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Cytotoxicity against normal human lung fibroblast MRC-5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Cytotoxicity against normal human lung fibroblast MRC-5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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42570380 |
| HCT-116 | CC50 |
8.8 μM
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Cytotoxicity against human colorectal carcinoma HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Cytotoxicity against human colorectal carcinoma HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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42570380 |
| HCT-116 | CC50 |
10.22 μM
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Cytotoxicity against human colorectal carcinoma HCT116 p53−/− cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
Cytotoxicity against human colorectal carcinoma HCT116 p53−/− cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay.
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42570380 |
In Vitro
Apoptosis inducer 63 (Compound 28) (0.32-160 μM; 72 h) exhibits highly potent growth inhibitory activity against A-431 cells with a CC50 of 3.71 μM[1].
Apoptosis inducer 63 (0.32-160 μM; 72 h) exhibits highly potent growth inhibitory activity against A-549 cells with a CC50 of 9.21 μM[1].
Apoptosis inducer 63 (0.32-160 μM; 72 h) exhibits highly potent growth inhibition against HCT116 cells, with a CC50 of 8.8 μM[1].
Apoptosis inducer 63 (5-40 μM; 96 h) induces apoptosis in both HCT116 and HCT116 p53−/− colorectal cancer cells, and at lower concentrations, the proportion of apoptotic cells is slightly higher in the p53-deficient cell line[1].
Apoptosis inducer 63 (20 μM) interferes with cell cycle progression in HCT116 and HCT116 p53−/− cells by inducing G2/M phase arrest and subsequent G1 phase accumulation, independent of p53 status[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 and HCT116 p53−/−
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Concentration:5-40 μM
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Incubation Time:96 h
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Result:Detected a substantial number of apoptotic cells in untreated samples, which increased significantly following treatment with 40 μM.
Detected a significantly higher proportion of apoptotic cells in the p53−/− line after treatment with 10 μM for 2-3 days and with 20 μM for 1-3 days.
Chemical Information
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CAS No. 872984-72-0
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Molecular Weight 431.44
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Formula C23H21N5O4
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SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3NC4=CC=C5C(CC6=C5C=CC=C6)=C4)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 63 Related Classifications
HY-189359 Related Classifications
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