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Cat. No.: HY-N21594

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Azedarachin B

Azedarachin B is a tetranortriterpenoid limonoid analog that is isolated and extracted from the root bark of Melia toosendan and the roots of Melia azedarach. Azedarachin B exhibits potent insecticidal activity and tumor cytotoxicity. Azedarachin B can be used in research on cancer and biopesticides.

For research use only. We do not sell to patients.

CAS No.: 197457-99-1
Formula: C₃₂H₄₂O₁₁
Molecular Weight:602.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Azedarachin B Chemical Structure

CAS No.: 197457-99-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	4.9 nM	Cytotoxicity against human KB cells. Cytotoxicity against human KB cells.	16880676

In Vitro

Azedarachin B shows highly potent lethality in the brine shrimp lethality test with an LC₅₀ of 0.0098 µM^[1].
Azedarachin B demonstrates potent cytotoxic activity against KB cells with an IC₅₀ of 0.0049 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Azedarachin B (50-500 ppm; topical; leaf disk) exhibits antifeedant activity against third-instar larvae of Spodoptera littoralis with a minimum inhibitory concentration of 200 ppm^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Spodoptera littoralis (Boisduval) (third-instar larvae)^[2]
Dosage:

50, 100, 150, 200, 300, 400, 500 ppm
Administration:

Topical; leaf disk; 2-24 h
Result:

Exhibited antifeedant activity with a minimum inhibitory concentration of 200 ppm.

Chemical Information

CAS No. 197457-99-1
Molecular Weight 602.67
Formula C₃₂H₄₂O₁₁
SMILES

C[C@]12[C@]34[C@]([C@H](C5=COC=C5)C[C@@]3([H])O4)([C@H](C([C@]1([H])[C@@]67[C@@]([C@@]([C@@H](OC6)OC(C(C)C)=O)([C@@H](C[C@@H]7O)OC(C)=O)C)([H])C[C@H]2O)=O)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fukuyama Y, et al. Degraded and oxetane-bearing limonoids from the roots of Melia azedarach. Chemical & pharmaceutical bulletin. 2006 Aug;54(8):1219-22.

[2]. Zhou J, et al. Antifeeding Limonoids from Melia toosendan. Heterocycles 45 (1997): 1781-1786.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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