Coumoxystrobin
Coumoxystrobin is a methoxyacrylate strobilurin fungicide with anti-fungal activity. Coumoxystrobin exhibits inhibitory activity against mycelial growth of Magnaporthe oryzae, increases cell membrane permeability, and reduces respiration. Coumoxystrobin shows protective activity against Magnaporthe oryzae in detached barley leaves. Coumoxystrobin reduces ATP activity of Chlorella vulgaris, thereby causing algal death. Coumoxystrobin can be used in studies related to rice blast disease.
For research use only. We do not sell to patients.
- CAS No.: 850881-70-8
- Formula: C26H28O6
- Molecular Weight:436.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Coumoxystrobin (0.0025-0.08 μg/mL; 7 days) potently inhibits mycelial growth of 100 strains of Magnaporthe oryzae, with a mean EC50 value of 0.0163 μg·mL−1[1].
Coumoxystrobin (0.1 μg/mL; 3 days) exerts teratogenic effects on the mycelial growth of Magnaporthe oryzae strains L-14, L-15 and YE-9, causing mycelial tip distortion and increased apical branching[1].
Coumoxystrobin (0.1 μg/mL; 48 h) disrupts the cell membrane permeability of Magnaporthe oryzae strains L-15 and YE-9, resulting in increased cellular electrolyte leakage[1].
Coumoxystrobin (0.1 μg/mL) significantly reduces the cellular respiration rates of Magnaporthe oryzae strains L-15 and YE-9[1].
Coumoxystrobin (1-4 μg/mL) exhibits dose-dependent protective activity against the YE-9 strain of *Magnaporthe oryzae* on detached barley leaves[1].
Coumoxystrobin (0.5-8 mg/L; 96 h) exhibits acute toxicity to Chlorella vulgaris, with an EC50 of 1.62 mg/L. After 96 h of exposure, the concentration of 4.23 mg/L reduces cell yield by 97.8%[2].
Coumoxystrobin (0.15-1.08 mg/L; 24-96 h) inhibits mitochondrial complex Ⅲ activity and reduces ATP viability in Chlorella vulgaris[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Chlorella vulgaris (FACHB-8)
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Concentration:0.5, 1.0, 2.0, 4.0 and 8.0 mg/L
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Incubation Time:96 h
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Result:Exhibited acute toxicity to Chlorella vulgaris, with an EC50 of 1.62 mg/L, after 96 h of exposure, the concentration of 4.23 mg/L reduces cell yield by 97.8%.
Chemical Information
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CAS No. 850881-70-8
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Molecular Weight 436.50
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Formula C26H28O6
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SMILES
CC=1C=2C(=CC(OCC3=C(\C(\C(OC)=O)=C/OC)C=CC=C3)=CC2)OC(=O)C1CCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
Purity & Documentation
References
[1]. Xin W, et al. In vitro fungicidal activity and in planta control efficacy of coumoxystrobin against Magnaporthe oryzae. Pestic Biochem Physiol. 2020;162:78-85. [Content Brief]
[2]. Wang K, et al. Respiratory Toxicity of Azoxystrobin, Pyraclostrobin and Coumoxystrobin on Chlorella vulgaris. Bull Environ Contam Toxicol. 2020;104(6):799-803. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Coumoxystrobin Related Classifications
HY-W715389 Related Classifications
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