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Cat. No.: HY-128028

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DAB-1

DAB-1 is an α-glucosidase and β-glucosidase inhibitor. DAB-1 also inhibits α-mannosidase, with an IC₅₀ of 49 μM against Jack bean α-mannosidase. DAB-1 exhibits IC₅₀ values of 7.8 μM and 0.69 μM against rice and Saccharomyces cerevisiae α-glucosidase, respectively, while its IC₅₀ values were 79 μM and 62 μM against almond and Aspergillus niger β-glucosidase, respectively. DAB-1 can be used in research related to metabolic diseases.

For research use only. We do not sell to patients.

CAS No.: 100937-52-8
Formula: C₅H₁₁NO₃
Molecular Weight:133.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DAB-1 Chemical Structure

CAS No.: 100937-52-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

β-Glucosidase

α‑glucosidase

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	1 μM Compound: 1, D-AB1	Inhibition of glucagon-stimulated glycogenolysis in Wistar rat hepatocytes assessed as glucose release after 90 mins Inhibition of glucagon-stimulated glycogenolysis in Wistar rat hepatocytes assessed as glucose release after 90 mins	[PMID: 18258441]
Hepatocyte	IC₅₀	1 μM Compound: D-AB1	Inhibition of basal glycogenolysis in rat primary hepatocytes Inhibition of basal glycogenolysis in rat primary hepatocytes	[PMID: 18595718]
Hepatocyte	IC₅₀	1 μM Compound: M1, DAB	Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysis Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysis	[PMID: 23378626]
Hepatocyte	IC₅₀	1.1 μM Compound: M1, DAB	Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysis Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysis	[PMID: 23378626]
Hepatocyte	IC₅₀	9 μM Compound: D-AB1	Inhibition of glucagon-induced glucose production in rat primary hepatocytes Inhibition of glucagon-induced glucose production in rat primary hepatocytes	[PMID: 18595718]
MOLT-4	CC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells	[PMID: 7608901]
MOLT-4	EC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells	[PMID: 7608901]
MT4	CC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of growth of mock-infected MT-4 cells Concentration giving 50% inhibition of growth of mock-infected MT-4 cells	[PMID: 7608901]
MT4	EC₅₀	>100 mg/mL Compound: 4	Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells	[PMID: 7608901]

In Vitro

DAB-1 (1 mM; pre-incubation for 5 minutes; reaction for 10-15 minutes) shows weak inhibition against Aspergillus orizae β-galactosidase, Aspergillus niger α-rhamnosidase, green coffee bean α-galactosidase, and jack bean β-N-acetylglucosaminidase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Double or multiplex chromogenic IHC

Chemical Information

CAS No. 100937-52-8
Molecular Weight 133.15
Formula C₅H₁₁NO₃
SMILES

C(O)[C@@H]1[C@@H](O)[C@H](O)CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lamara KO, et al. A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold. Molecules (Basel, Switzerland). 2025 Jan 08;30(2):226.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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