MXRA8 - matrix remodeling associated 8 Gene

Also Known as ASP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54587

About MXRA8

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,352,689-1,363,541 (from NCBI)

This gene has 10 transcripts (splice variants), 249 orthologues and 14 paralogues. Broad expression in gall bladder (RPKM 26.7), fat (RPKM 25.8) and 22 other tissues.

Summary

Predicted to be involved in establishment of glial blood-brain barrier. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

MXRA8 Products (5)

mRNA Protein Name
NM_001282582.2 NP_001269511.1 matrix remodeling-associated protein 8 isoform 2 precursor
NM_001282583.2 NP_001269512.1 matrix remodeling-associated protein 8 isoform 4
NM_001282584.2 NP_001269513.1 matrix remodeling-associated protein 8 isoform 3 precursor
NM_001282585.1 NP_001269514.1 matrix remodeling-associated protein 8 isoform 1 precursor
NM_032348.4 NP_115724.1 matrix remodeling-associated protein 8 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MXRA8 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (38 - 145)

V-set

V-set: Immunoglobulin V-set domain (171 - 277)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

matrix remodeling-associated protein 8

  • limitrin

MXRA8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MXRA8 Q9BRK3 CABP2 Homo sapiens Q9NPB3
Validated Y2H
32296183
Intra
MXRA8 Q9BRK3 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
MXRA8 Q9BRK3 GMEB2 Homo sapiens Q9UKD1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MXRA8 Proteins

Cat. No. Product Name Accession Purity
HY-P700876 MXRA8 Protein, Human (HEK293, His) Q9BRK3-1 (V20-Q341) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chikungunya

  • Chikungunya Fever

  • Arbovirus A Chikungunya Type

  • Chik

  • Chikv Infection

  • Ck

  • Chikungunya Virus Infection

  • Chikungunya Haemorrhagic Fever

  • Chikungunya Viral Disease

  • Chikungunya Mosquito-Borne Viral Fever
Ross River Fever

  • Ross River Virus Disease

  • Ross River Virus Infection
Necatoriasis

  • Miner'S Anaemia

  • Negro Cachexia

  • Dochmiasis

  • Ground Itch Disease

  • Brickmaker'S Chlorosis

  • Coolie Itch Anaemia

  • Cachexia Aquosa

  • Dew Itch Anaemia

  • Brickmaker'S Anaemia

  • Tunnel Worker'S Anaemia

  • Egyptian Anaemia

  • Tunnel Worker'S Disease

  • Miner'S Cachexia

  • Greisinger Disease

  • Tropical Chlorosis

  • Egyptian Chlorosis

  • Tunnel Anaemia

  • Dochmiosis

  • Necatorosis

  • African Cachexia

  • Water Itch Anaemia

  • Infection Due To Necator Americanus

  • St Gotthard Disease

  • Gotthard Tunnel Disease
Esophageal Adenosquamous Carcinoma
Western Equine Encephalitis

  • Western Equine Encephalomyelitis

  • Wee

  • Encephalomyelitis, Western Equine

  • Western Equine Encephalitis Virus Infection

  • Wee - [Western Equine Encephalitis]

  • Western Equine Encephalitis Virus
Autoimmune Optic Neuritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08867 MXRA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20995 Mxra8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27512 Mxra8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MXRA8 VGNC VGNC:107587
Bos taurus MXRA8 VGNC VGNC:50222
Macaca mulatta MXRA8 VGNC VGNC:75088
Mus musculus MXRA8 MGD MGI:1922011
Canis familiaris MXRA8 VGNC VGNC:53426
Rattus norvegicus MXRA8 RGD RGD:1359356
Others MXRA8 NCBI