PTTG1IP - PTTG1 interacting protein Gene

Also Known as PBF; C21orf1; C21orf3; PTTG1IP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 754

Summary

This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic Fibroblast Growth Factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Ubiquitous expression in placenta (RPKM 104.1), gall bladder (RPKM 88.0) and 25 other tissues.

PTTG1IP Products (1)

mRNA Protein Name
NG_033966.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables p53 binding IPI
IPI: Inferred from physical interaction
24506068 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
24506068 GOA
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
24506068 GOA
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
24506068 GOA
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
10781616 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10781616 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10781616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTTG1IP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTTG1IP P53801 LDLRAD1 Homo sapiens Q5T700
Y2H Array
25416956
Intra
PTTG1IP P53801 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
PTTG1IP P53801 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
PTTG1IP P53801 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
PTTG1IP P53801 CLEC7A Homo sapiens Q9BXN2-6
Validated Y2H
32296183
Intra
PTTG1IP P53801 CLEC7A Homo sapiens Q9BXN2-6
Y2H Array
32296183
Intra
PTTG1IP P53801 CLEC7A Homo sapiens Q9BXN2-6
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 SLC22A23 Homo sapiens A1A5C7-2
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 SLC22A23 Homo sapiens A1A5C7-2
Y2H Array
32296183
Intra
PTTG1IP P53801 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
PTTG1IP P53801 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
PTTG1IP P53801 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
PTTG1IP P53801 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
PTTG1IP P53801 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
PTTG1IP P53801 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
PTTG1IP P53801 ATP6AP2 Homo sapiens O75787
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 ATP6AP2 Homo sapiens O75787
Y2H Array
32296183
Intra
PTTG1IP P53801 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
PTTG1IP P53801 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
PTTG1IP P53801 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 CLEC7A Homo sapiens Q9BXN2
Validated Y2H
25416956
Intra
PTTG1IP P53801 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
Intra
PTTG1IP P53801 SGCB Homo sapiens Q16585
Validated Y2H
32296183
Intra
PTTG1IP P53801 SGCB Homo sapiens Q16585
Y2H Prey Pooling
32296183
Intra
PTTG1IP P53801 SGCB Homo sapiens Q16585
Y2H Array
32296183
Intra
PTTG1IP P53801 PTGS1 Homo sapiens P23219
Validated Y2H
32814053
Intra
PTTG1IP P53801 PTGS1 Homo sapiens P23219
Y2H Pooling
32814053
Intra
PTTG1IP P53801 PTGS1 Homo sapiens P23219
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction