HAUS3 - HAUS augmin like complex subunit 3 Gene

Also Known as IT1; dgt3; C4orf15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79441

About HAUS3

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,228,349-2,242,121 (from NCBI)

This gene has 5 transcripts (splice variants) and 192 orthologues. Ubiquitous expression in bone marrow (RPKM 19.8), lymph node (RPKM 8.7) and 24 other tissues.

Summary

This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and Mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA Polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

HAUS3 Products (2)

mRNA Protein Name
NM_001303143.2 NP_001290072.1 HAUS augmin-like complex subunit 3
NM_024511.7 NP_078787.2 HAUS augmin-like complex subunit 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19369198 GOA
Biological Process GO Annotation Evidence References Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
19427217 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
19369198 GOA
Cellular Component GO Annotation Evidence References Source
part of HAUS complex IDA
IDA: Inferred from direct assay
19369198 GOA
part of HAUS complex IPI
IPI: Inferred from physical interaction
20360068 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
30723163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS3 Protein Structure

HAUS-augmin3

HAUS-augmin3: HAUS augmin-like complex subunit 3 (29 - 283)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
Protein Preferred Names Protein Names

HAUS augmin-like complex subunit 3

HAUS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HAUS3 Q68CZ6 GNG13 Homo sapiens Q9P2W3
Validated Y2H
32296183
Intra
HAUS3 Q68CZ6 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
HAUS3 Q68CZ6 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
HAUS3 Q68CZ6 HAUS6 Homo sapiens Q7Z4H7
TAP
24981860
Intra
HAUS3 Q68CZ6 TXLNA Homo sapiens P40222
Y2H Prey Pooling
32296183
Intra
HAUS3 Q68CZ6 TXLNA Homo sapiens P40222
Y2H Array
32296183
Intra
HAUS3 Q68CZ6 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra
HAUS3 Q68CZ6 BRME1 Homo sapiens Q0VDD7
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Baritosis

  • Deposition Of Barium In The Lungs

  • Inhalation Of Barytes
Cystic Basal Cell Carcinoma

  • Skin Cystic Basal Cell Carcinoma
Micronodular Basal Cell Carcinoma

  • Skin Micronodular Basal Cell Carcinoma

  • Basal Cell Carcinoma, Micronodular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06015 HAUS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HAUS3 VGNC VGNC:62756
Macaca mulatta HAUS3 VGNC VGNC:73252
Canis familiaris HAUS3 VGNC VGNC:41604
Rattus norvegicus HAUS3 RGD RGD:1591723
Mus musculus HAUS3 MGD MGI:2387633
Bos taurus HAUS3 VGNC VGNC:29759
Others HAUS3 NCBI