GALP - galanin like peptide Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85569

About GALP

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:56,176,008-56,185,775 (from NCBI)

This gene has 3 transcripts (splice variants) and 52 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the Galanin family of neuropeptides. The encoded protein binds Galanin receptors 1, 2 and 3 with the highest affinity for Galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]

GALP Products (2)

mRNA Protein Name
NM_001145546.2 NP_001139018.1 galanin-like peptide isoform 2 precursor
NM_033106.4 NP_149097.1 galanin-like peptide isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
23537644 GOA
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
23537644 GOA
involved in modulation of process of another organism IMP
IMP: Inferred from mutant phenotype
23537644 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALP Protein Structure

Galanin

Galanin: Galanin (33 - 45)

  • 0
  • 100
  • 116 a.a.
Protein Preferred Names Protein Names

galanin-like peptide

  • alarin

GALP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GALP Q9UBC7 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
GALP Q9UBC7 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
GALP Q9UBC7 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
GALP Q9UBC7 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
GALP Q9UBC7 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ganglioneuroblastoma
Ganglioneuroma
Inflammatory Bowel Disease 25

  • Early Onset Autosomal Recessive Inflammatory Bowel Disease 25

  • Ibd25

  • Inflammatory Bowel Disease 25, Autosomal Recessive
Spherocytosis, Type 3

  • Hereditary Spherocytosis Type 3

  • SPH3

  • Hs3

  • Spherocytosis, Hereditary, 3

  • Hereditary Spherocytosis 3

  • Spherocytosis 3
Cardiomyopathy, Dilated, 1p

  • Dilated Cardiomyopathy 1p

  • CMD1P

  • Cardiomyopathy, Dilated 1p

  • Cardiomyopathy, Dilated, Type 1p
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5894 human GALP (3-32) Antagonist / Unkown
HY-RS05263 GALP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180407 UGM-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GALP VGNC VGNC:41099
Mus musculus GALP MGD MGI:2663979
Rattus norvegicus GALP RGD RGD:620187
Macaca mulatta GALP VGNC VGNC:72775
Others GALP NCBI