MEGA-10
Based on 1 Customer Validation
MEGA-10 (N-Oxodecyl meglumine) is a nonionic sugar-based surfactant. MEGA-10 sequesters n-alkylbenzenes into its hydrophobic core via micelle formation as a solubilizer.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 85261-20-7
- Formula: C17H35NO6
- Molecular Weight:349.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MEGA-10 can solubilize benzene, toluene, ethylbenzene, n-propylbenzene, n-butylbenzene, n-pentylbenzene, and n-hexane above its critical micelle concentration (cmc), and the solubilization affinity increases with the elongation of the alkyl chain length of solubilizates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 85261-20-7
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Appearance Solid
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Molecular Weight 349.46
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Formula C17H35NO6
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Color White to off-white
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SMILES
O[C@@H](CN(C)C(CCCCCCCCC)=O)[C@@H](O)[C@H](O)[C@H](O)CO
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Synonyms
N-Oxodecyl meglumine; Decanoyl N-methylglucamide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 66.67 mg/mL (190.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (14.31 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (14.31 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Basu Ray G, et al. On mixed binary surfactant systems comprising MEGA 10 and alkyltrimethylammonium bromides: a detailed physicochemical study with a critical analysis. J Colloid Interface Sci. 2007;307(2):543-553. [Content Brief]
[2]. Nakamura S, et al. Solubilization of n-alkylbenzenes into decanoyl-N-methylglucamide (Mega-10) solution. Langmuir. 2008 Jan 1;24(1):15-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8616 mL | 14.3078 mL | 28.6156 mL | 71.5389 mL |
| 5 mM | 0.5723 mL | 2.8616 mL | 5.7231 mL | 14.3078 mL | |
| 10 mM | 0.2862 mL | 1.4308 mL | 2.8616 mL | 7.1539 mL | |
| 15 mM | 0.1908 mL | 0.9539 mL | 1.9077 mL | 4.7693 mL | |
| 20 mM | 0.1431 mL | 0.7154 mL | 1.4308 mL | 3.5769 mL | |
| 25 mM | 0.1145 mL | 0.5723 mL | 1.1446 mL | 2.8616 mL | |
| 30 mM | 0.0954 mL | 0.4769 mL | 0.9539 mL | 2.3846 mL | |
| 40 mM | 0.0715 mL | 0.3577 mL | 0.7154 mL | 1.7885 mL | |
| 50 mM | 0.0572 mL | 0.2862 mL | 0.5723 mL | 1.4308 mL | |
| 60 mM | 0.0477 mL | 0.2385 mL | 0.4769 mL | 1.1923 mL | |
| 80 mM | 0.0358 mL | 0.1788 mL | 0.3577 mL | 0.8942 mL | |
| 100 mM | 0.0286 mL | 0.1431 mL | 0.2862 mL | 0.7154 mL |
MEGA-10 Related Classifications
HY-W040217 Related Classifications
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- MEGA-10
- 85261-20-7
- N-Oxodecyl
- Decanoyl N-methylglucamide
- MEGA10
- MEGA 10
- Environmental Pollutants
- Biochemical Assay Reagents
- critical micelle concentration
- membrane-solubilizing amphiphile
- micelles
- n-alkylbenzenes
- N-methyl-N-decanoyl glucamide
- hydrophobic cores
- toluene
- benzene
- nonionic sugar-based surfactant
- ethylbenzene
- Inhibitor
- inhibitor
- inhibit