WEE2
WEE2, also called Wee1B, is the oocyte-specific paralog of WEE1 and shares its ability to phosphorylate the inhibitory Tyr15 of CDK1. Its defining role is in female meiosis: WEE2 keeps cyclin B-CDK1 inactive in growing oocytes and contributes to maintaining meiotic arrest until the luteinizing hormone surge, after which its activity must be extinguished for meiotic resumption and fertilization. Biallelic loss-of-function mutations in WEE2 cause oocyte maturation arrest and female infertility, a Mendelian phenotype not seen with somatic WEE1. Beyond the germline, WEE2 expression is reported in a subset of tumors. Recombinant WEE2 serves meiosis and fertility research.
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WEE2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
