YD-3
YD-3 is a platelet activation inhibitor. YD-3 inhibits Thrombine-induced rabbit platelets aggregation (IC50: 28.3 μM) and phosphoinositol production. In addition, YD-3 also inhibits Trypsin-induced platelet aggregation in human and rabbit with the IC50 of 38.1 μM and 5.7 μM, respectively, but does not affect the proteolytic activity of trypsin.
For research use only. We do not sell to patients.
- CAS No.: 170632-41-4
- Formula: C23H20N2O2
- Molecular Weight:356.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
>10 μM
Compound: YD-3
|
Inhibition of collagen-induced human platelet aggregation
Inhibition of collagen-induced human platelet aggregation
|
[PMID: 17988878] |
| Platelet | IC50 |
>10 μM
Compound: YD-3
|
Inhibition of SFLLRN-induced human platelet aggregation
Inhibition of SFLLRN-induced human platelet aggregation
|
[PMID: 17988878] |
| Platelet | IC50 |
>10 μM
Compound: YD-3
|
Inhibition of thrombin-induced human platelet aggregation
Inhibition of thrombin-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
>10 μM
Compound: YD-3
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Inhibition of U46619-induced human platelet aggregation
Inhibition of U46619-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
0.13 μM
Compound: YD-3
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Inhibition of GYPGKF-induced human platelet aggregation
Inhibition of GYPGKF-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
164 μM
Compound: 11
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Inhibition of PAF-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by PAF addition
Inhibition of PAF-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by PAF addition
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[PMID: 33049608] |
| Platelet | IC50 |
184.8 μM
Compound: 11
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Inhibition of arachidonic acid-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by arachidonic acid addition
Inhibition of arachidonic acid-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by arachidonic acid addition
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[PMID: 33049608] |
| Platelet | IC50 |
212.4 μM
Compound: 11
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Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by collagen addition
Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by collagen addition
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[PMID: 33049608] |
| Platelet | IC50 |
29.3 μM
Compound: 11
|
Inhibition of thrombin-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by thrombin addition
Inhibition of thrombin-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by thrombin addition
|
[PMID: 33049608] |
Chemical Information
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CAS No. 170632-41-4
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Molecular Weight 356.42
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Formula C23H20N2O2
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SMILES
O=C(OCC)C1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YD-3 Related Classifications
HY-111766 Related Classifications
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