2. Metabolic Enzyme/Protease
  3. 11β-HSD
  4. DG 381B

DG 381B (compound 62) is a 11β-HSD1 and 11β-HSD2inhibitor.

For research use only. We do not sell to patients.

DG 381B

DG 381B Chemical Structure

CAS No. : 564-16-9

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DG 381B Related Antibodies

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Description

DG 381B (compound 62) is a 11β-HSD1 and 11β-HSD2inhibitor[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 2.2.15 CC50
161.68 μM
Compound: 42, 11-deoxo-GA
Cytotoxicity against human HepG2(2.2.15) cells
Cytotoxicity against human HepG2(2.2.15) cells
[PMID: 22520261]
HepG2 2.2.15 IC50
47 μM
Compound: 42, 11-deoxo-GA
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA replication
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA replication
[PMID: 22520261]
HepG2 2.2.15 IC50
48.66 μM
Compound: 42, 11-deoxo-GA
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B surface antigen release
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B surface antigen release
[PMID: 22520261]
HepG2 2.2.15 IC50
> 1374.78 μM
Compound: 42, 11-deoxo-GA
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B e-antigen release
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B e-antigen release
[PMID: 22520261]
RAW264.7 IC50
25.61 μM
Compound: 5
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 32299661]
Sf21 IC50
> 40 μM
Compound: 8
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
[PMID: 31774676]
Molecular Weight

456.70

Formula

C30H48O3
CAS No.
SMILES

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O)=O)C)C)([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DG 381B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DG 381B564-16-911β-HSD11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenase18b-glycyrrhetinic acid analogue11β-HSD inhibitorInhibitorinhibitorinhibit

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