1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Dianicline dihydrochloride

Dianicline dihydrochloride 

Cat. No.: HY-110241 Purity: 99.42%
Handling Instructions

Dianicline dihydrochloride is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation. Dianicline dihydrochloride increases cessation rates in a dose-dependent manner.

For research use only. We do not sell to patients.

Dianicline dihydrochloride Chemical Structure

Dianicline dihydrochloride Chemical Structure

CAS No. : 292634-27-6

Size Price Stock Quantity
1 mg USD 65 In-stock
Estimated Time of Arrival: December 31
5 mg USD 195 Get quote
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Dianicline dihydrochloride is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation. Dianicline dihydrochloride increases cessation rates in a dose-dependent manner[1].

Molecular Weight

289.20

Formula

C₁₃H₁₈Cl₂N₂O

CAS No.

292634-27-6

SMILES

[H][[email protected]]1(CC[[email protected]](CC2)C3)[[email protected]]32CC4=NC=CC=C4O1.[2HCl]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (86.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4578 mL 17.2891 mL 34.5781 mL
5 mM 0.6916 mL 3.4578 mL 6.9156 mL
10 mM 0.3458 mL 1.7289 mL 3.4578 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product name:
Dianicline dihydrochloride
Cat. No.:
HY-110241
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