2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Dibromomaleimide-C5-COOH

Dibromomaleimide-C5-COOH  (Synonyms: DBM-C5-COOH)

Cat. No.: HY-157080 Purity: 99.30%
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Dibromomaleimide-C5-COOH (DBM-C5-COOH) is a bifunctional dibromomaleimide (DBM) linker. Dibromomaleimide-C5-COOH can be used to connect MMAF and to synthesize ADC.

For research use only. We do not sell to patients.

Dibromomaleimide-C5-COOH Chemical Structure

Dibromomaleimide-C5-COOH Chemical Structure

CAS No. : 1443214-97-8

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Based on 1 publication(s) in Google Scholar

Dibromomaleimide-C5-COOH Related Antibodies

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Description

Dibromomaleimide-C5-COOH (DBM-C5-COOH) is a bifunctional dibromomaleimide (DBM) linker. Dibromomaleimide-C5-COOH can be used to connect MMAF and to synthesize ADC[1].

Molecular Weight

369.01

Formula

C10H11Br2NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCN1C(C(Br)=C(C1=O)Br)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (271.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7100 mL 13.5498 mL 27.0995 mL
5 mM 0.5420 mL 2.7100 mL 5.4199 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7100 mL 13.5498 mL 27.0995 mL 67.7488 mL
5 mM 0.5420 mL 2.7100 mL 5.4199 mL 13.5498 mL
10 mM 0.2710 mL 1.3550 mL 2.7100 mL 6.7749 mL
15 mM 0.1807 mL 0.9033 mL 1.8066 mL 4.5166 mL
20 mM 0.1355 mL 0.6775 mL 1.3550 mL 3.3874 mL
25 mM 0.1084 mL 0.5420 mL 1.0840 mL 2.7100 mL
30 mM 0.0903 mL 0.4517 mL 0.9033 mL 2.2583 mL
40 mM 0.0677 mL 0.3387 mL 0.6775 mL 1.6937 mL
50 mM 0.0542 mL 0.2710 mL 0.5420 mL 1.3550 mL
60 mM 0.0452 mL 0.2258 mL 0.4517 mL 1.1291 mL
80 mM 0.0339 mL 0.1694 mL 0.3387 mL 0.8469 mL
100 mM 0.0271 mL 0.1355 mL 0.2710 mL 0.6775 mL
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Dibromomaleimide-C5-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dibromomaleimide-C5-COOH1443214-97-8DBM-C5-COOHADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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