Dircin
Dircin is a daphnane-type diterpene ester natural product found in the branches and flowers of Dirca occidentalis A. Gray. It exhibits potent cytotoxicity against P-388 lymphocytic leukemia cells, with a ED50 of 0.00000025 μg/mL. Dircin can be used in studies of leukemia and plant-derived cytotoxic daphnane-type diterpene esters.
For research use only. We do not sell to patients.
- CAS No.: 88497-93-2
- Formula: C39H52O11
- Molecular Weight:696.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Dircin (compound II) potently inhibits P-388 lymphocytic leukemia cells in vitro, with an ED50 of 0.00000025 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Dircin (62.5 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a survival time T/C value of 147%[1].
Dircin (31.3 μg/kg; i.p.; over a 10-day period; P-388-bearing male CD2F1 mice) yields a survival time T/C value of 125%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six CD2F1 male P-388 tumor-bearing mice[1]
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Dosage:125 μg/kg
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Administration:Intraperitoneal administration over a 10-day period
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Result:Produced a survival T/C value of 156%.
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Animal Model:Six CD2F1 male P-388 tumor-bearing mice[1]
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Dosage:62.5 μg/kg
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Administration:Intraperitoneal administration over a 10-day period
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Result:Produced a survival T/C value of 147%.
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Animal Model:Six CD2F1 male P-388 tumor-bearing mice[1]
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Dosage:31.3 μg/kg
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Administration:Intraperitoneal administration over a 10-day period
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Result:Produced a survival T/C value of 125%.
Chemical Information
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CAS No. 88497-93-2
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Molecular Weight 696.83
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Formula C39H52O11
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SMILES
C[C@H]1[C@@]23[C@]4([C@]5([C@](CO)(O5)[C@@H](O)[C@@]6(O)[C@]2([C@]([C@H](C)[C@@H]6OC(=O)C7=CC=CC=C7)([C@@H](C)CCCCCC[C@@H](OC(C)=O)[C@@]8(O3)O[C@]4([C@](C(C)=C)(C1)O8)[H])[H])[H])[H])[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dircin Related Classifications
HY-187763 Related Classifications
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