Sodium pyrophosphate
Based on 1 publication(s) in Google Scholar
Sodium pyrophosphate (Disodium pyrophosphate) is an orally active reverse transcriptase ribonuclease H inhibitor. Sodium pyrophosphate forms soluble complexes with iron from ferric pyrophosphate to promote intestinal iron absorption. Sodium pyrophosphate increases the β-sheet content of oxidatively damaged myofibrillar protein gels and enhances the gastric digestibility and antioxidant activity of their digestion products. Sodium pyrophosphate prevents the degradation of RNA-DNA hybrids, inhibits antisense complementary DNA synthesis, induces phage DNA leakage, and causes random mutations in temperate phages.
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- Assay : 98.2%
- No. CAS: 7758-16-9
- Fòrmula: Na2H2P2O7
- Peso molecular:221.94
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Sodium pyrophosphate
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Actividad biológica
Descripciòn
In Vitro
Sodium pyrophosphate (2 mM; 12 h) significantly increases the gastric digestibility of myofibrillar protein gels prepared from oxidatively damaged porcine longissimus dorsi muscle, but does not alter their intestinal digestibility[2].
Sodium pyrophosphate (2 mM; 12 h) increases the β-sheet content in undigested myofibrillar protein gels prepared from oxidatively damaged porcine longissimus dorsi muscle, which helps enhance gastric digestibility, and the protein undergoes a typical structural transition to β-turn during gastrointestinal digestion[2].
Sodium pyrophosphate (2 mM; 12 h) alters the microstructure of oxidatively damaged myofibrillar protein gels from porcine longissimus dorsi muscle, making it similar to that of non-oxidized gels; it also generates gastric digestion products with a rougher, more porous structure, which is associated with improved digestibility[2].
Sodium pyrophosphate (2 mM; 12 h) shifts the molecular distribution of gastrointestinal digestion products of oxidatively damaged porcine longissimus dorsi myofibrillar protein gels toward smaller peptide fragments, reduces particle size, and increases the absolute negative value of ζ-potential[2].
Sodium pyrophosphate (4 mM; 15-90 min) inhibits anti-complementary DNA synthesis and stabilizes DNA-RNA hybrids during poliovirus RNA cDNA synthesis catalyzed by avian myeloblastosis virus reverse transcriptase, thereby increasing the yield of full-length 18S poliovirus cDNA[3].
Sodium pyrophosphate (4 mM; 10-60 min) inhibits avian myeloblastosis reverse transcriptase-mediated degradation of isolated poliovirus DNA-RNA hybrids and suppresses anti-complementary DNA synthesis using this hybrid as a template[3].
Sodium pyrophosphate (4 mM; 5-60 min) maintains the nuclease resistance of isolated poliovirus DNA-RNA hybrids during incubation with avian myeloblastosis virus reverse transcriptase, even in the absence of active DNA synthesis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 7758-16-9
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Appearance Solid
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Peso molecular 221.94
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Fòrmula Na2H2P2O7
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Color White to off-white
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SMILES
[Na2H2P2O7]
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Synonyms
Disodium pyrophosphate; Sodium acid pyrophosphate; SAPP
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227
Solvente y solubilidad
In Vitro:
H2O : 100 mg/mL (450.57 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5057 mL | 22.5286 mL | 45.0572 mL | 112.6431 mL |
| 5 mM | 0.9011 mL | 4.5057 mL | 9.0114 mL | 22.5286 mL | |
| 10 mM | 0.4506 mL | 2.2529 mL | 4.5057 mL | 11.2643 mL | |
| 15 mM | 0.3004 mL | 1.5019 mL | 3.0038 mL | 7.5095 mL | |
| 20 mM | 0.2253 mL | 1.1264 mL | 2.2529 mL | 5.6322 mL | |
| 25 mM | 0.1802 mL | 0.9011 mL | 1.8023 mL | 4.5057 mL | |
| 30 mM | 0.1502 mL | 0.7510 mL | 1.5019 mL | 3.7548 mL | |
| 40 mM | 0.1126 mL | 0.5632 mL | 1.1264 mL | 2.8161 mL | |
| 50 mM | 0.0901 mL | 0.4506 mL | 0.9011 mL | 2.2529 mL | |
| 60 mM | 0.0751 mL | 0.3755 mL | 0.7510 mL | 1.8774 mL | |
| 80 mM | 0.0563 mL | 0.2816 mL | 0.5632 mL | 1.4080 mL | |
| 100 mM | 0.0451 mL | 0.2253 mL | 0.4506 mL | 1.1264 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium pyrophosphate Related Classifications
HY-W105970 Related Classifications
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Keywords
- Sodium pyrophosphate
- 7758-16-9
- Disodium pyrophosphate
- Sodium acid pyrophosphate
- SAPP
- DNA/RNA Synthesis
- complementary DNA
- avian myeloblastosis virus reverse transcriptase
- phage virion
- porcine longissimus lumborum myofibrillar protein
- Staphylococcus aureus
- iron bioavailability
- Caco-2 cell
- RNA-DNA hybrid
- ribonuclease H
- iron deficiency
- Inhibitor
- inhibitor
- inhibit