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Cat. No.: HY-182395

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DM175

DM175 is a partial agonist of FXR. DM175 binds to the ligand-binding domain of FXR and induces the outward movement of Trp454.

For research use only. We do not sell to patients.

CAS No.: 832119-34-3
Formula: C₂₅H₂₄N₂O₄
Molecular Weight:416.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DM175 Chemical Structure

CAS No.: 832119-34-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

DM175 is a partial agonist of FXR. DM175 binds to the ligand-binding domain of FXR and induces the outward movement of Trp454^[1].

In Vitro

DM175 is a partial agonist of FXR LBD, which induces the outward movement of Trp454, a conformational change distinct from that induced by full FXR agonists^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 832119-34-3
Molecular Weight 416.47
Formula C₂₅H₂₄N₂O₄
SMILES

O=C(C1=CC=C(NC(C2=C(NC(C3=CC=C(C(C)(C)C)C=C3)=O)C=CC=C2)=O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miyata S, et al. Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists. Sci Rep. 2021;11(1):9196. Published 2021 Apr 28. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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