Cbx5 - chromobox 5 Gene

Also Known as HP1; Hp1a; Hp1alpha; 2610029O15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12419

Summary

Enables several functions, including histone deacetylase binding activity; identical protein binding activity; and methylated histone binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in chromocenter; chromosomal region; and nucleolus. Part of histone deacetylase complex; Histone Methyltransferase complex; and transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CBX5 (chromobox 5). [provided by Alliance of Genome Resources, Apr 2022]

Cbx5 Products (4)

mRNA Protein Name
NM_001076789.2 NP_001070257.1 chromobox protein homolog 5
NM_001110216.1 NP_001103686.1 chromobox protein homolog 5
NM_001358950.1 NP_001345879.1 chromobox protein homolog 5
NM_007626.3 NP_031652.1 chromobox protein homolog 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
12242305 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
10318760 MGI
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
12242305 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
8978696 MGI
enables methylated histone binding IPI
IPI: Inferred from physical interaction
16127177 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8978696 MGI
enables protein-macromolecule adaptor activity IPI
IPI: Inferred from physical interaction
12242305 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10562550 MGI
Cellular Component GO Annotation Evidence References Source
located in chromocenter IDA
IDA: Inferred from direct assay
17284516 MGI
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
20110566 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
10318760 MGI
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
12242305 MGI
part of histone methyltransferase complex IDA
IDA: Inferred from direct assay
12242305 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
14519686 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
10318760 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10318760 MGI
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
20110566 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
12242305 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromobox protein homolog 5

  • HP1 alpha

  • chromobox homolog 5

  • heterochromatin protein 1 alpha

  • heterochromatin protein 1 homolog alpha

  • mHP1(alpha)

Cbx5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cbx5 Q61686 Senp7 Mus musculus Q8BUH8
Anti Tag CoIP
22388734
Intra
Cbx5 Q61686 Trim24 Mus musculus Q64127
Y2H
8978696
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142952 UNC6864 (Kei) Inhibitor / Unkown
HY-142953 UNC6349 (Ket2) Inhibitor / Unkown
HY-142954 UNC6212 (Kme2) Inhibitor / Unkown
HY-181089 CBX2-IN-1 Inhibitor / Unkown
HY-RS02012 CBX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19580 Cbx5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26077 Cbx5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbx5 NCBI NCBI:23468