CRY1 - cryptochrome circadian regulator 1 Gene

Also Known as DSPD; PHLL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1407

About CRY1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,991,364-107,093,549 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

CRY1 Products (14)

mRNA Protein Name
NM_001413458.1 NP_001400387.1 cryptochrome-1 isoform a
NM_001413459.1 NP_001400388.1 cryptochrome-1 isoform b
NM_001413460.1 NP_001400389.1 cryptochrome-1 isoform c
NM_001413461.1 NP_001400390.1 cryptochrome-1 isoform d
NM_001413462.1 NP_001400391.1 cryptochrome-1 isoform d
NM_001413463.1 NP_001400392.1 cryptochrome-1 isoform e
NM_001413464.1 NP_001400393.1 cryptochrome-1 isoform f
NM_001413465.1 NP_001400394.1 cryptochrome-1 isoform f
NM_001413466.1 NP_001400395.1 cryptochrome-1 isoform g
NM_001413467.1 NP_001400396.1 cryptochrome-1 isoform h
NM_001413468.1 NP_001400397.1 cryptochrome-1 isoform h
NM_001413469.1 NP_001400398.1 cryptochrome-1 isoform h
NM_001413470.1 NP_001400399.1 cryptochrome-1 isoform h
NM_004075.5 NP_004066.1 cryptochrome-1 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables DNA (6-4) photolyase activity IDA
IDA: Inferred from direct assay
8909283 GOA
NOT enables deoxyribodipyrimidine photo-lyase activity IDA
IDA: Inferred from direct assay
8909283 GOA
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
9801304 GOA
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
22170608 GOA
enables phosphatase binding IPI
IPI: Inferred from physical interaction
9383998 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9383998 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12397359 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12397359 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
26431207 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRY1 Protein Structure

DNA_photolyase

DNA_photolyase: DNA photolyase (5 - 159)

FAD_binding_7

FAD_binding_7: FAD binding domain of DNA photolyase (212 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 586 a.a.
Protein Preferred Names Protein Names

cryptochrome-1

  • cryptochrome 1 (photolyase-like)

CRY1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CRY1 Q16526 PRMT5 Homo sapiens O14744
Anti Tag CoIP
23133559
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Delayed Sleep Phase Disorder

  • Delayed Sleep Phase Syndrome

  • Delayed Sleep Phase Syndrome, Susceptibility To

  • DSPD

  • Delayed Sleep Phase Disorder, Susceptibility To

  • DSPS

  • Sleep Phase, Delayed, Disorder

  • Sleep Phase Syndrome, Delayed, Susceptibility To
Sleep Disorder

  • Sleep Disorders

  • Non-Organic Sleep Disorder
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Sleep Apnea

  • Sleep Apnea Syndromes
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Apnea, Obstructive Sleep

  • Obstructive Sleep Apnea Syndrome

  • Obstructive Sleep Apnea

  • Sleep Apnea, Obstructive

  • Osa

  • Osas

  • Sleep Apnea/Hypopnea Syndrome

  • Sahs

  • Upper Airway Resistance Sleep Apnea Syndrome

  • Apnea, Obstructive

  • Obstructive Apnea

  • Osahs

  • Sleep Apnea Hypopnea Syndrome

  • Sleep Apnea Syndrome, Obstructive

  • Sleep Apnea Obstructive

  • Sleep Apnea Syndromes

  • Obstructive Sleep Apnoea Syndrome

  • Obstructive Sleep Apnoea, Adult

  • Osa - [Obstructive Sleep Apnoea]

  • Obstructive Sleep Apnoea, Paediatric

  • Obstructive Sleep Apnoea Hypopnoea Syndrome

  • Osa Syndrome

  • Sleep Apnoea Nos

  • [Sas] - Sleep Apnoea Syndrome

  • Sleep Apnoea Syndrome

  • [Osahs] - Obstructive Sleep Apnoea-Hypopnea Syndrome

  • [Sahs] - Sleep Apnoea-Hypopnea Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115672 KS15 Inhibitor 99.46% Unkown
HY-148764 M47 Degrader 99.96% Unkown
HY-134193 KL101 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CRY1 VGNC VGNC:71499
Bos taurus CRY1 VGNC VGNC:27730
Felis catus CRY1 VGNC VGNC:61195
Canis familiaris CRY1 VGNC VGNC:39633
Mus musculus CRY1 MGD MGI:1270841
Rattus norvegicus CRY1 RGD RGD:735083
Others CRY1 NCBI