ADRA2C - adrenoceptor alpha 2C Gene

Also Known as ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152

About ADRA2C

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,766,385-3,768,526 (from NCBI)

This gene has 2 transcripts (splice variants), 228 orthologues, 18 paralogues and is associated with 1 phenotype.

Summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

ADRA2C Products (1)

mRNA Protein Name
NM_000683.4 NP_000674.2 alpha-2C adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-2A adrenergic receptor binding IPI
IPI: Inferred from physical interaction
16605244 GOA
enables alpha2-adrenergic receptor activity EXP
EXP: Inferred from Experiment
10948191 GOA
enables alpha2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
17215105 GOA
enables epinephrine binding IDA
IDA: Inferred from direct assay
17215105 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16531006 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
16605244 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
16605244 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
17215105 GOA
involved in activation of protein kinase B activity IDA
IDA: Inferred from direct assay
17215105 GOA
involved in adrenergic receptor signaling pathway IDA
IDA: Inferred from direct assay
17215105 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
17215105 GOA
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
17215105 GOA
involved in receptor transactivation IDA
IDA: Inferred from direct assay
17215105 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16605244 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16605244 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADRA2C Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (68 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

alpha-2C adrenergic receptor

  • adrenergic, alpha-2C-, receptor

ADRA2C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADRA2C P18825 P4HA3 Homo sapiens Q7Z4N8
Validated Y2H
32296183
Intra
ADRA2C P18825 CNPY2 Homo sapiens Q9Y2B0
Validated Y2H
32296183
Intra
ADRA2C P18825 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
32296183
Intra
ADRA2C P18825 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
ADRA2C P18825 CHCHD2 Homo sapiens Q9Y6H1
Validated Y2H
32296183
Intra
ADRA2C P18825 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
ADRA2C P18825 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra
ADRA2C P18825 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ADRA2C P18825 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
ADRA2C P18825 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Raynaud Disease

  • Raynaud'S Disease

  • Raynaud Phenomenon

  • Raynaud'S Syndrome

  • Raynaud'S

  • Cold Fingers, Hereditary

  • Raynaud'S Phenomenon

  • Raynaud'S Disease/Phenomenon

  • Raynauds Syndrome

  • Raynauds Phenomenon

  • Secondary Raynaud'S Phenomenon

  • Raynaud Syndrome
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Type 1 Diabetes Mellitus 22

  • Diabetes Mellitus, Insulin-Dependent, 22

  • IDDM22

  • T1D22

  • Insulin-Dependent Diabetes Mellitus 22

  • Diabetes Mellitus, Insulin-Dependent, Type 22
Long Qt Syndrome

  • Romano-Ward Syndrome

  • Long Q-T Syndrome

  • Lqt

  • Qt Syndrome, Long

  • Congenital Long Qt Syndrome

  • Familial Long Qt Syndrome
Horner'S Syndrome

  • Horner Syndrome

  • Bernard-Horner Syndrome

  • Oculosympathetic Palsy

  • Bernard Horner Syndrome

  • Cervical Sympathetic Paralysis

  • Von Passow Syndrome

  • Cervical Sympathetic Dystrophy
Long Qt Syndrome 1

  • Romano-Ward Syndrome

  • LQT1

  • Ward-Romano Syndrome

  • Rws

  • Ventricular Fibrillation With Prolonged Qt Interval

  • Wrs

  • Long Qt Syndrome 1, Acquired, Susceptibility To

  • Long Qt Syndrome 1, Acquired

  • Romano-Ward Long Qt Syndrome

  • Long Qt Syndrome Type 1

  • Long Qt Syndrome-1

  • Acquired Susceptibility To Long Qt Syndrome 1

  • Qt Syndrome, Long, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00413 ADRA2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20136 Adra2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26639 Adra2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADRA2C MGD MGI:87936
Macaca mulatta ADRA2C VGNC VGNC:69727
Rattus norvegicus ADRA2C RGD RGD:2058
Felis catus ADRA2C VGNC VGNC:59657
Bos taurus ADRA2C VGNC VGNC:106633
Others ADRA2C NCBI