SIRT5 - sirtuin 5 Gene

Also Known as SIR2L5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23408

About SIRT5

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:13,574,274-13,615,158 (from NCBI)

This gene has 24 transcripts (splice variants), 265 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 3.7), liver (RPKM 2.6) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the Sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

SIRT5 Products (43)

mRNA	Protein	Name
NM_001376798.1	NP_001363727.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_047418518.1	XP_047274474.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
NM_001376815.1	NP_001363744.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 8
XM_047418524.1	XP_047274480.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
XM_047418514.1	XP_047274470.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1
XM_047418515.1	XP_047274471.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1
NM_001376814.1	NP_001363743.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7
XM_047418522.1	XP_047274478.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
XM_047418519.1	XP_047274475.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
NR_164856.1
NM_001376802.1	NP_001363731.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376808.1	NP_001363737.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2
NM_001376806.1	NP_001363735.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_017010620.3	XP_016866109.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
NM_001376803.1	NP_001363732.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376804.1	NP_001363733.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376812.1	NP_001363741.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4
NM_001376813.1	NP_001363742.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7
NM_001376811.1	NP_001363740.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 6
NM_001376805.1	NP_001363734.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NR_164852.1
NM_001242827.1	NP_001229756.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4
NR_164853.1
XM_017010624.3	XP_016866113.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X5
NM_001376810.1	NP_001363739.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5
NM_001193267.2	NP_001180196.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 3
NM_012241.5	NP_036373.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_047418521.1	XP_047274477.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
XM_047418526.1	XP_047274482.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4
XM_047418525.1	XP_047274481.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4
XM_047418527.1	XP_047274483.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4
XM_024446388.2	XP_024302156.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X6
XM_047418523.1	XP_047274479.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
NM_001376800.1	NP_001363729.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376799.1	NP_001363728.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376809.1	NP_001363738.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5
NM_001376801.1	NP_001363730.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376807.1	NP_001363736.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_047418517.1	XP_047274473.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
XM_047418520.1	XP_047274476.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
XM_047418516.1	XP_047274472.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1
NR_164854.1
NM_031244.3	NP_112534.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD+ binding	IDA IDA: Inferred from direct assay	21908771	GOA
enables protein-glutaryllysine deglutarylase activity	IDA IDA: Inferred from direct assay	24703693	GOA
enables protein-malonyllysine demalonylase activity	IDA IDA: Inferred from direct assay	21908771	GOA
enables protein-succinyllysine desuccinylase activity	IDA IDA: Inferred from direct assay	21908771	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	22076378	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	24140062	GOA
involved in peptidyl-lysine demalonylation	IDA IDA: Inferred from direct assay	21908771	GOA
involved in peptidyl-lysine desuccinylation	IDA IDA: Inferred from direct assay	21908771	GOA
NOT involved in protein deacetylation	IDA IDA: Inferred from direct assay	22076378	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	18680753	GOA
involved in protein deglutarylation	IDA IDA: Inferred from direct assay	24703693	GOA
involved in protein demalonylation	IDA IDA: Inferred from direct assay	24703693	GOA
involved in protein desuccinylation	IDA IDA: Inferred from direct assay	24140062	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	23806337	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	18680753	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	18680753	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16079181	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT5 Protein Structure

SIR2

0
100
200
310 a.a.

Protein Preferred Names	Protein Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial	NAD-dependent deacetylase sirtuin-5 NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial silent mating type information regulation 2, S.cerevisiae, homolog 5 sir2-like 5 sirtuin type 5

Recombinant SIRT5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74545	SIRT5 Protein, Human (Flag)	Q9NXA8-1/NP_036373.1 (R2-S310)	≥ 95%, as determined by reducing SDS-PAGE.

SIRT5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80321	SIRT5 Antibody (YA079)	WB	Human

Related Diseases

Diseases	Alias
Monckeberg Arteriosclerosis	Monckeberg Medial Calcific Sclerosis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0879A	Suramin sodium salt	Inhibitor	99.98%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145651	Et-29	Inhibitor	99.89%	Unkown
HY-146387	SIRT5 inhibitor 3	Inhibitor	98.0%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	98.37%	Unkown
HY-168681	Sirtuin-IN-2	Inhibitor	/	Unkown
HY-152214	SIRT5 inhibitor 5	Inhibitor	/	Unkown
HY-184000	SIRT5-IN-10	Inhibitor	/	Unkown
HY-146386	SIRT5 inhibitor 2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SIRT5	VGNC	VGNC:46186
Rattus norvegicus	SIRT5	RGD	RGD:1303285
Macaca mulatta	SIRT5	VGNC	VGNC:77485
Mus musculus	SIRT5	MGD	MGI:1915596
Felis catus	SIRT5	VGNC	VGNC:65159
Bos taurus	SIRT5	VGNC	VGNC:34634
Others	SIRT5	NCBI