KLRB1 - killer cell lectin like receptor B1 Gene

Also Known as NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3820

About KLRB1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,594,551-9,607,916 (from NCBI)

This gene has 1 transcript (splice variant), 326 orthologues and 23 paralogues. Broad expression in bone marrow (RPKM 31.5), spleen (RPKM 28.1) and 14 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

KLRB1 Products (1)

mRNA Protein Name
NM_002258.3 NP_002249.1 killer cell lectin-like receptor subfamily B member 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21572041 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRB1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (114 - 212)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

killer cell lectin-like receptor subfamily B member 1

  • C-type lectin domain family 5 member B

KLRB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLRB1 Q12918 CLEC2D Homo sapiens Q9UHP7-1
SPR
21572041
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRB1 Proteins

Cat. No. Product Name Accession Purity
HY-P72750 CD161 Protein, Human (HEK293, Fc) Q12918 (Q67-S225) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78085 CD161 Protein, Human (Biotinylated, HEK293, His-Avi) Q12918 (Q67-S225) ≥ 95%, as determined by Bis-Tris PAGE.

KLRB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80966 CD161 Antibody (YA853) WB, IHC-P, FC Human
HY-P84969 CD161 Antibody (YA4661)

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 18

  • IBD18
Dermatitis, Atopic, 5

  • ATOD5

  • Atopic Dermatitis 5

  • Dermatitis, Atopic, Susceptibility To, 5

  • Dermatitis, Atopic 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0028 Forsythiaside A 99.79% Unkown
HY-RS07390 KLRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17834 Klrb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24302 Klrb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992251 Anti-KLRB1 Antibody / Unkown
HY-P992427 NST0036 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KLRB1 RGD RGD:1586149
Macaca mulatta KLRB1 VGNC VGNC:99948
Canis familiaris KLRB1 VGNC VGNC:42485
Bos taurus KLRB1 VGNC VGNC:30684
Others KLRB1 NCBI