MGAT1 - alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Gene

Also Known as GnTI; MGAT; GLCT1; GLYT1; GNT-1; GNT-I; GLCNAC-TI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4245

About MGAT1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,784,780-180,815,616 (from NCBI)

This gene has 25 transcripts (splice variants), 249 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 30.2), spleen (RPKM 29.9) and 25 other tissues.

Summary

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

MGAT1 Products (23)

mRNA Protein Name
NM_001114617.2 NP_001108089.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001114618.1 NP_001108090.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001114619.1 NP_001108091.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001114620.1 NP_001108092.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364377.2 NP_001351306.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364379.2 NP_001351308.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364380.2 NP_001351309.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364381.2 NP_001351310.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364382.2 NP_001351311.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364383.2 NP_001351312.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364384.2 NP_001351313.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364385.2 NP_001351314.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364386.2 NP_001351315.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364387.2 NP_001351316.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364388.2 NP_001351317.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364389.2 NP_001351318.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364390.2 NP_001351319.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364391.2 NP_001351320.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364392.2 NP_001351321.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364393.2 NP_001351322.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364394.2 NP_001351323.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_001364395.2 NP_001351324.1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
NM_002406.4 NP_002397.2 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
1702225 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
1702225 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30983867 GOA
Biological Process GO Annotation Evidence References Source
involved in protein N-linked glycosylation via asparagine IDA
IDA: Inferred from direct assay
1702225 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
20378551 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGAT1 Protein Structure

GNT-I

GNT-I: GNT-I family (12 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

  • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I

MGAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MGAT1 P26572 BRI3 Homo sapiens O95415
Y2H
30983867
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cataract 1, Multiple Types

  • Cataract 1 Multiple Types

  • CTRCT1

  • Cataract 1, Multiple Types, With Or Without Microcornea

  • Czp1

  • Cae1

  • Pulverulent Zonular Cataract

  • Cataract, Duffy-Linked

  • Cataract, Zonular Pulverulent, 1

  • Duffy Linked Cataract

  • Zonular Pulverulent Cataract 1

  • Cataract Duffy-Linked

  • Cataract-Microcornea Syndrome

  • Cataract Zonular Pulverulent 1

  • Ccmc

  • Cznp

  • Czp

  • Zonular Nuclear Pulverulent Cataract

  • Cataract, Zonular Pulverulent-1

  • Zonular Pulverulent Cataract

  • Cataract, Zonular Pulverulent 1

  • Cataract Microcornea Syndrome
Progressive Familial Heart Block, Type Ib

  • Progressive Familial Heart Block Type Ib

  • PFHB1B

  • Pfhbib

  • Progressive Familial Heart Block Type 1b

  • Heart Block Progressive Familial Type 1b

  • Progressive Familial Heart Block 1b

  • Cardiac Conduction Block

  • Right-Bundle Branch Block

  • Heart Block, Familial, Progressive, Type 1b

  • Heart Block

  • Right Bundle Branch Block
Muscle Eye Brain Disease

  • Muscle-Eye-Brain Disease

  • Muscle-Eye-Brain Syndrome

  • Meb

  • Muscular Dystrophy-Dystroglycanopathy Congenital With Brain And Eye Anomalies A3

  • Meb Syndrome

  • Santavuori Congenital Muscular Dystrophy
Congenital Disorder Of Glycosylation, Type Iia

  • CDG2A

  • Congenital Disorder Of Glycosylation Type Iia

  • Cdg Iia

  • Cdgiia

  • Congenital Disorder Of Glycosylation Type 2a

  • Alkuraya Syndrome

  • Mental Retardation, Growth Retardation, Prominent Columella, And Open Mouth

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii

  • Mgat2-Cdg

  • Cdg-Iia

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii, Formerly

  • Cdgs2, Formerly

  • Cdgs2

  • Cdg Syndrome Type Iia

  • Carbohydrate Deficient Glycoprotein Syndrome Type Iia

  • N-Acetylglucosaminyltransferase 2 Deficiency

  • Congenital Disorder Of Glycosylation 2a

  • Carbohydrate-Deficient Glycoprotein Syndrome Type Ii

  • Cdgs Type Ii

  • Carbohydrate-Deficient Glycoprotein Syndrome Type 2

  • Glycosylation, Congenital Disorder Of, Type Iia
Congenital Disorder Of Glycosylation, Type In

  • Congenital Disorder Of Glycosylation

  • CDG1N

  • Congenital Disorders Of Glycosylation

  • Cdg In

  • Cdgin

  • Congenital Disorder Of Glycosylation 1n

  • Carbohydrate-Deficient Glycoprotein Syndrome

  • Cdg

  • Rft1-Cdg

  • Cdg-In

  • Congenital Disorder Of Glycosylation Type In

  • Carbohydrate Deficient Glycoprotein Syndrome

  • Cdg Syndrome

  • Congenital Disorder Of Glycosylation In

  • Carbohydrate-Deficient Glycoprotein Syndromes

  • Cdg Syndrome Type In

  • Carbohydrate Deficient Glycoprotein Syndrome Type In

  • Congenital Disorder Of Glycosylation Type 1n

  • Man5glcnac2-Pp-Dol Flippase Deficiency

  • Glycosylation, Congenital Disorder Of

  • Glycosylation, Congenital Disorder Of, Type In
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-138942 PF-06427878 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103504 (S)-SNAP5114 Inhibitor 98.09% Unkown
HY-118207 LU-32-176B Inhibitor / Unkown
HY-155305 BuChE-IN-9 Inhibitor / Unkown
HY-185701 W-GTF01 Inhibitor / Unkown
HY-E70144 N-Acetylglucosaminyltransferase 1 / Unkown
HY-RS08399 MGAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08584 MOGAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21645 Mgat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28163 Mgat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MGAT1 VGNC VGNC:84439
Bos taurus MGAT1 VGNC VGNC:54623
Canis familiaris MGAT1 VGNC VGNC:81792
Mus musculus MGAT1 MGD MGI:96973
Rattus norvegicus MGAT1 RGD RGD:620097
Others MGAT1 NCBI