VAMP8 - vesicle associated membrane protein 8 Gene

Also Known as EDB; VAMP-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8673

About VAMP8

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,577,586-85,582,031 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 10 paralogues. Ubiquitous expression in colon (RPKM 79.3), placenta (RPKM 77.9) and 24 other tissues.

Summary

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

VAMP8 Products (1)

mRNA Protein Name
NM_003761.5 NP_003752.2 vesicle-associated membrane protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride channel inhibitor activity IDA
IDA: Inferred from direct assay
18570918 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19557002 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
23217709 GOA
involved in autophagosome membrane docking IDA
IDA: Inferred from direct assay
25686604 GOA
NOT involved in eosinophil degranulation IMP
IMP: Inferred from mutant phenotype
16677249 GOA
involved in mucus secretion IMP
IMP: Inferred from mutant phenotype
22144578 GOA
involved in negative regulation of secretion by cell IDA
IDA: Inferred from direct assay
12130530 GOA
NOT involved in neutrophil degranulation IMP
IMP: Inferred from mutant phenotype
16677249 GOA
involved in positive regulation of histamine secretion by mast cell IMP
IMP: Inferred from mutant phenotype
18253931 GOA
involved in regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
18570918 GOA
acts upstream of or within symbiont entry into host cell IMP
IMP: Inferred from mutant phenotype
24550300 GOA
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
12130530 GOA
located in azurophil granule membrane IDA
IDA: Inferred from direct assay
16677249 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18253931 GOA
located in cytosol IDA
IDA: Inferred from direct assay
22589474 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
23217709 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
23217709 GOA
located in membrane IDA
IDA: Inferred from direct assay
16677249 GOA
located in mucin granule IDA
IDA: Inferred from direct assay
22144578 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18570918 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18253931 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
18570918 GOA
located in secretory granule membrane IDA
IDA: Inferred from direct assay
16677249 GOA
located in vesicle IDA
IDA: Inferred from direct assay
18570918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP8 Protein Structure

Synaptobrevin

Synaptobrevin: Synaptobrevin (10 - 96)

  • 0
  • 100 a.a.
Protein Preferred Names Protein Names

vesicle-associated membrane protein 8

  • vesicle-associated membrane protein 8 (endobrevin)

VAMP8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VAMP8 Q9BV40 STX17 Homo sapiens P56962
Anti Tag CoIP
23217709
Intra
VAMP8 Q9BV40 STX7 Homo sapiens O15400
Anti Tag CoIP
19557002
Intra
VAMP8 Q9BV40 STX7 Homo sapiens O15400
Anti Tag CoIP
33422265
Intra
VAMP8 Q9BV40 SNAP29 Homo sapiens O95721
Anti Tag CoIP
35271311
Intra
VAMP8 Q9BV40 SNAP29 Homo sapiens O95721
Anti Tag CoIP
23217709
Cross: Cross-species interaction Intra: Intraspecies interaction

VAMP8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81807 VAMP8 Antibody (YA1552) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P81807A VAMP8 Antibody (YA1552)(PBS only) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Familial Hemophagocytic Lymphohistiocytosis 5

  • Fhl5

  • Hlh5

  • Hplh5

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 5
Hemophagocytic Lymphohistiocytosis, Familial, 4

  • Familial Hemophagocytic Lymphohistiocytosis 4

  • FHL4

  • Hplh4

  • Hlh4

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Hermansky-Pudlak Syndrome 2

  • HPS2

  • Hermansky Pudlak Syndrome 2

  • Platelet Defects And Oculocutaneous Albinism

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 2

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

  • Catecholaminergic Polymorphic Ventricular Tachycardia 1

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • CPVT1

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Cvpt1

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Ventricular Tachycardia Catecholaminergic Polymorphic 1

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation

  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Vici Syndrome

  • Absent Corpus Callosum Cataract Immunodeficiency

  • VICIS

  • Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum

  • Dionisi Vici Sabetta Gambarara Syndrome

  • Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum

  • Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome

  • Dionisi-Vici-Sabetta-Gambarara Syndrome

  • Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15599 VAMP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19045 Vamp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25535 Vamp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VAMP8 VGNC VGNC:36760
Rattus norvegicus VAMP8 RGD RGD:620421
Mus musculus VAMP8 MGD MGI:1336882
Felis catus VAMP8 VGNC VGNC:66914
Canis familiaris VAMP8 VGNC VGNC:48227
Macaca mulatta VAMP8 VGNC VGNC:78754
Others VAMP8 NCBI