STX17 - syntaxin 17 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55014

About STX17

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,906,654-99,974,534 (from NCBI)

This gene has 12 transcripts (splice variants), 169 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 7.7), skin (RPKM 7.1) and 25 other tissues.

Summary

Enables SNAP receptor activity; SNARE binding activity; and protein Phosphatase binding activity. Involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Acts upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum-Golgi intermediate compartment; and mitochondria-associated endoplasmic reticulum membrane. Part of SNARE complex. Colocalizes with HOPS complex. [provided by Alliance of Genome Resources, Apr 2022]

STX17 Products (1)

mRNA	Protein	Name
NM_017919.3	NP_060389.2	syntaxin-17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNAP receptor activity	IMP IMP: Inferred from mutant phenotype	23217709	GOA
enables SNARE binding	IDA IDA: Inferred from direct assay	23217709	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23217709	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	23006999	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	21545355	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	28306502	GOA
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	23217709	GOA
involved in autophagosome membrane docking	IDA IDA: Inferred from direct assay	25686604	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	21545355	GOA
involved in endoplasmic reticulum-Golgi intermediate compartment organization	IMP IMP: Inferred from mutant phenotype	21545355	GOA
acts upstream of or within protein localization to phagophore assembly site	IDA IDA: Inferred from direct assay	23455425	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of HOPS complex	IDA IDA: Inferred from direct assay	24554770	GOA
part of SNARE complex	IDA IDA: Inferred from direct assay	23217709	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	25686604	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	23217709	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23217709	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	23006999	GOA
NOT located in lysosomal membrane	IDA IDA: Inferred from direct assay	10930465	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	23455425	GOA
NOT located in mitochondrion	IDA IDA: Inferred from direct assay	10930465	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23217709	GOA
NOT located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	10930465	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX17 Protein Structure

SNARE

0
100
200
302 a.a.

Protein Preferred Names	Protein Names
syntaxin-17

STX17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STX17	P56962	ACSL3	Homo sapiens	O95573	Anti Tag CoIP	29549094
Intra	STX17	P56962	ACSL3	Homo sapiens	O95573	PLA	29549094
Intra	STX17	P56962	VPS41	Homo sapiens	P49754	Anti Tag CoIP	24554770
Intra	STX17	P56962	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	24554770
Intra	STX17	P56962	VPS16	Homo sapiens	Q9H269	Anti Tag CoIP	24554770
Intra	STX17	P56962	VPS16	Homo sapiens	Q9H269	Confocal	24554770
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	25419848
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	23217709
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Bait CoIP	25419848
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	33422265
Cross	STX17	P56962	Vamp7	Mus musculus	P70280	Anti Tag CoIP	23217709
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Tag CoIP	23217709
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Bait CoIP	25419848
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Tag CoIP	33422265
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Tag CoIP	25419848

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melanomatosis
Vici Syndrome	Absent Corpus Callosum Cataract Immunodeficiency VICIS Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum Dionisi Vici Sabetta Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome Dionisi-Vici-Sabetta-Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Alopecia Universalis Congenita	Alopecia Universalis ALUNC Atrichia, Generalized Au Alopecia Areata Universalis Atrichia Generalized
Pontiac Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152100	CUR5g	Inhibitor	98.69%	Unkown
HY-RS13978	STX17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17615	Stx17 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24075	Stx17 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STX17	MGD	MGI:1914977
Rattus norvegicus	STX17	RGD	RGD:708499
Macaca mulatta	STX17	VGNC	VGNC:78042
Felis catus	STX17	VGNC	VGNC:65808
Bos taurus	STX17	VGNC	VGNC:35433
Canis familiaris	STX17	VGNC	VGNC:46951
Others	STX17	NCBI