Mudanpioside E
Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases.
For research use only. We do not sell to patients.
- CAS No.: 172705-25-8
- Formula: C24H30O13
- Molecular Weight:526.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mudanpioside E (10.0-100.0 μM) potently inhibits IgE-mediated β-hexosaminidase release (a marker of degranulation) in RBL-2H3 cells, with an IC50 of 40.34 μM, and shows no cytotoxicity even at concentrations as high as 100.0 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddY mice (6-week-old, male)[1]
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Dosage:0.55 mg/kg; 1.1 mg/kg; 2.2 mg/kg (all co-administered with Peony root-depleted Shoseiryuto-extract at 0.57 g/kg)
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Administration:p.o.; single dose
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Result:Significantly counteracted the suppressive effect of Peony root-depleted Shoseiryuto-extract on the PCA reaction in a dose-dependent manner at 0.55, 1.1, and 2.2 mg/kg.
Did not exhibit any effect on the PCA reaction when administered alone at 2.2 mg/kg.
Chemical Information
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CAS No. 172705-25-8
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Molecular Weight 526.49
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Formula C24H30O13
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SMILES
O=C(C1=CC(OC)=C(C=C1)O)OC[C@@]23[C@]4([C@]5(O[C@]2([H])O[C@@]([C@]3([H])C4)(C5)O)C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Tsukamoto K, et al. Counteractive effect of Paeonia lactiflora root constituent mudanpioside E against suppressive effect of Shoseiryuto-extract on passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol. 2014;153(3):884-889. [Content Brief]
[2]. Shi YH, et al. Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora. J Nat Med. 2016;70(2):234-240. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mudanpioside E Related Classifications
HY-N18182 Related Classifications
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