S26131
Based on 12 publication(s) in Google Scholar
S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist.
For research use only. We do not sell to patients.
- Purity: 99.63%
- CAS No.: 296280-56-3
- Formula: C31H34N2O4
- Molecular Weight:498.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) S26131
More- Autophagy. 2026 Jun 25:1-16. [Abstract]
- J Nanobiotechnology. 2021 Sep 4;19(1):263. [Abstract]
- Int J Biol Sci. 2022 Mar 6;18(5):2202-2219. [Abstract]
- Immun Ageing. 2024 Sep 5;21(1):59. [Abstract]
- J Pineal Res. 2024 Sep;76(6):e13006. [Abstract]
- J Pineal Res. 2022 Nov;73(4):e12833. [Abstract]
- Eur J Pharmacol. 2021 Dec 5:912:174589. [Abstract]
- Cell Oncol (Dordr). 2026 Jun 23. [Abstract]
- Front Pharmacol. 2021 Sep 16:12:719313. [Abstract]
- Chem Eng Sci. 2024 Aug 5, 295, 120129.
- Sci Rep. 2022 Oct 21;12(1):17686. [Abstract]
- Res Sq. 2025 Jul 28.
Biological Activity
Chemical Information
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CAS No. 296280-56-3
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Appearance Solid
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Molecular Weight 498.61
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Formula C31H34N2O4
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Color Off-white to light brown
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SMILES
CC(NCCC1=C2C=C(C=CC2=CC=C1)OCCCOC3=CC=C4C=CC=C(C4=C3)CCNC(C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (12)
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Journal Impact Factor
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Most Recent
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Autophagy
2026 Jun 25:1-16. PMID: 42290138 -
J Nanobiotechnology
3D-printing magnesium-polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures. [Abstract]2021 Sep 4;19(1):263. PMID: 34481503 -
Int J Biol Sci
Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/Gαi2/YAP signaling. [Abstract]2022 Mar 6;18(5):2202-2219. PMID: 35342351 -
Immun Ageing
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway. [Abstract]2024 Sep 5;21(1):59. PMID: 39237911 -
J Pineal Res
Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine-Induced Conditioned Place Preference and Sensitization in Mice. [Abstract]2024 Sep;76(6):e13006. PMID: 39221552 -
J Pineal Res
Melatonin promotes the proliferation of primordial germ cell-like cells derived from porcine skin-derived stem cells: A mechanistic analysis. [Abstract]2022 Nov;73(4):e12833. PMID: 36106819 -
Eur J Pharmacol
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. [Abstract]2021 Dec 5:912:174589. PMID: 34699755 -
Cell Oncol (Dordr)
Tasimelteon inhibits glioma proliferation by inducing ferroptosis via the SP1/ACSL4 pathway. [Abstract]2026 Jun 23. PMID: 42334777 -
Front Pharmacol
Notoginsenoside R1 Reverses Abnormal Autophagy in Hippocampal Neurons of Mice With Sleep Deprivation Through Melatonin Receptor 1A. [Abstract]2021 Sep 16:12:719313. PMID: 34603030 -
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Sci Rep
Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors. [Abstract]2022 Oct 21;12(1):17686. PMID: 36271291 -
Solvent & Solubility
DMSO : 31.25 mg/mL (62.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (2.51 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.25 mg/mL (2.51 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0056 mL | 10.0279 mL | 20.0558 mL | 50.1394 mL |
| 5 mM | 0.4011 mL | 2.0056 mL | 4.0112 mL | 10.0279 mL | |
| 10 mM | 0.2006 mL | 1.0028 mL | 2.0056 mL | 5.0139 mL | |
| 15 mM | 0.1337 mL | 0.6685 mL | 1.3371 mL | 3.3426 mL | |
| 20 mM | 0.1003 mL | 0.5014 mL | 1.0028 mL | 2.5070 mL | |
| 25 mM | 0.0802 mL | 0.4011 mL | 0.8022 mL | 2.0056 mL | |
| 30 mM | 0.0669 mL | 0.3343 mL | 0.6685 mL | 1.6713 mL | |
| 40 mM | 0.0501 mL | 0.2507 mL | 0.5014 mL | 1.2535 mL | |
| 50 mM | 0.0401 mL | 0.2006 mL | 0.4011 mL | 1.0028 mL | |
| 60 mM | 0.0334 mL | 0.1671 mL | 0.3343 mL | 0.8357 mL |
S26131 Related Classifications
HY-122136 Related Classifications
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