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16 Results for "

paracellular pathways

" in MedChemExpress (MCE) Product Catalog:

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Deoxynivalenol

21 Publications Verification

Cat. No.: HY-N6684

CAS No.: 51481-10-8

Synonyms: Vomitoxin

Category:

Microorganisms Terpenoids Sesquiterpenes Metabolic Disease Disease Research Fields

Target:

P-glycoprotein

Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

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Famotidine

7 Cited Publications

Cat. No.: HY-B0377

CAS No.: 76824-35-6

Synonyms: MK-208

Target:

Histamine Receptor MMP Toll-like Receptor (TLR) ERK

Research Areas:

Infection Metabolic Disease Inflammation/Immunology

Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer .

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DSPE-PEG2000-OH

1 Cited Publications

Cat. No.: HY-140741

Purity: 99.89%

Target:

Biochemical Assay Reagents

Research Areas:

Inflammation/Immunology

DSPE-PEG2000-OH is an absorption enhancer. DSPE-PEG2000-OH reduces the expression levels of ZO-1 and Occludin. DSPE-PEG2000-OH enhances the pulmonary absorption of poorly absorbable macromolecules via the paracellular pathway without altering pulmonary membrane fluidity .

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Decyl β-D-maltopyranoside

Cat. No.: HY-W040203

CAS No.: 82494-09-5

Decyl β-D-maltopyranoside is an epithelial permeability enhancer. Decyl β-D-maltopyranoside regulates the paracellular transport pathway and increases the permeability of molecules and proteins transported via the paracellular route. Decyl β-D-maltopyranoside enhances the transepithelial paracellular permeability of EPO across cell monolayers .

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Secretin, canine TFA

Cat. No.: HY-P1784A

Target:

Secretin Receptor

Research Areas:

Endocrinology

ecretin, canine TFA is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine TFA can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway .

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