DMG-PEG2000-KTP

DMG-PEG2000-KTP is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. KTP peptide: Targeting/functional ligand-KTP peptide is a kidney-targeting peptide that can directionally deliver carriers to kidney tissue, increasing renal drug accumulation, and simultaneously redirecting carriers originally enriched in the liver to the kidneys.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.