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Cat. No.: HY-187409A

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DOPE-PEG2000-MTP

Name: DOPE-PEG2000-MTP
Brand: MedChemExpress
SKU: HY-187409A
Availability: PreOrder

(Synonyms: DOPE-PEG2000-Mal-Cys-ASSLNIA)

DOPE-PEG2000-MTP (DOPE-PEG2000-Mal-Cys-ASSLNIA) is an amphiphilic lipid-PEG-peptide conjugate consisting of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the MTP (mitochondria-targeting peptide). MTP peptide functions as a mitochondria-directed targeting ligand. DOPE-PEG2000-MTP is designed for functionalizing nanocarriers to deliver drugs specifically to mitochondria.

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보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-MTP Chemical Structure

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Biological Activity

제품 설명

In Vitro

DOPE-PEG2000-MTP: functionalization of liposomes and nanoparticles for mitochondria-targeted drug delivery, particularly for pro-apoptotic agents, reactive oxygen species (ROS) modulators, and mitochondria-damaging therapeutics in cancer therapy.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two unsaturated oleoyl chains that anchors into lipid bilayers and facilitates membrane fusion and endosomal escape;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces protein adsorption and RES clearance, and extends circulation time;
(3) MTP peptide; a mitochondria-targeting peptide that exploits mitochondrial membrane potential to accumulate in mitochondria, enabling selective delivery of cargo to this organelle for modulating mitochondrial function and inducing apoptosis in target cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-MTP]
Synonyms

DOPE-PEG2000-Mal-Cys-ASSLNIA
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.