Dorzolamide-d5(hydrochloride)
Dorzolamide-d5(hydrochloride) (L671152 hydrochloride-d5) is deuterium labeled Dorzolamide (hydrochloride). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2749856-75-3
- Formula: C10H12D5ClN2O4S3
- Molecular Weight:365.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-B0553
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20-HETE-d6Stable Isotope -
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DL-Phenylalanine-d5Stable Isotope -
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Brinzolamide-d5Stable Isotope -
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Mitoxantrone-d8Stable Isotope -
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Nor-W-18-d4Stable Isotope -
HY-103641AS1
(2R)-Octyl-α-hydroxyglutarate-d17Stable Isotope -
HY-W004305S
Hexadecanal-d5Stable Isotope
Biological Activity
Description
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2749856-75-3
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Unlabeled CAS 130693-82-2
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Molecular Weight 365.93
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Formula C10H12D5ClN2O4S3
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SMILES
O=S1([C@H](C[C@@H](C2=C1SC(S(N)(=O)=O)=C2)NC([2H])(C([2H])([2H])[2H])[2H])C)=O.Cl
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Synonyms
L671152 hydrochloride-d5; MK507 hydrochlorid-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Belal M Ali, et al. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1271-82. [Content Brief]
[3]. J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60. [Content Brief]
[4]. Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dorzolamide-d5(hydrochloride) Related Classifications
HY-B0109AS1 Related Classifications
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