DPPE-PEG2000-T7

DPPE-PEG2000-T7 is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against transferrin receptor (TfR/CD71) on the surface of cancer cells and brain endothelial cells.
Composition and role of each component:
1. DPPE (dipalmitoylphosphatidylethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchorage; its saturated C16 chains confer bilayer rigidity.
2. PEG2000 (polyethylene glycol, MW 2000): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
3. T7 (T7 peptide (HAIYPRH)): Targeting ligand-a 7-amino acid peptide that binds to transferrin receptor (TfR/CD71), which is highly expressed on many rapidly proliferating cancer cells and brain capillary endothelial cells. Enables receptor-mediated transcytosis across the blood-brain barrier and targeted delivery to TfR-positive tumor cells as a non-immunogenic alternative to full-length transferrin. Target: transferrin receptor (TfR/CD71) on the surface of cancer cells and brain endothelial cells.

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