EGFR-IN-219
EGFR-IN-219 is an EGFR inhibitor. EGFR-IN-219 induces Apoptosis and G0/G1 cell cycle arrest. EGFR-IN-219 exhibits selective anticancer activity against lung adenocarcinoma. EGFR-IN-219 can be used for research on non-small cell lung cancer.
For research use only. We do not sell to patients.
- Formula: C17H11BrN4O4S
- Molecular Weight:447.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6.10 μM
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Cytotoxicity against human A549 lung adenocarcinoma cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity against human A549 lung adenocarcinoma cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
|
42612271 |
| L929 | IC50 |
>500 μM
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Cytotoxicity against mouse L929 embryonic fibroblast cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity against mouse L929 embryonic fibroblast cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
|
42612271 |
| A549 | IC50 |
2.68 μM
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Inhibition of EGFR in human A549 lung adenocarcinoma cells incubated for 24 hrs by colorimetric In-Cell ELISA assay.
Inhibition of EGFR in human A549 lung adenocarcinoma cells incubated for 24 hrs by colorimetric In-Cell ELISA assay.
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42612271 |
In Vitro
EGFR-IN-219 (Compound 2b) (24 h) exhibits potent and selective cytotoxicity against A549 lung adenocarcinoma cells, with an IC50 of 6.10 μM[1].
EGFR-IN-219 (6.10 μM; 24 h) induces apoptosis in A549 cells, with an early apoptosis rate of 7.13% and a late apoptosis rate of 1.60%, although its high cytotoxic potency may involve non-apoptotic cell death modes[1].
EGFR-IN-219 (6.10 μM; 24 h) induces cell cycle arrest at the G0/G1 phase in A549 cells, with 65.23% of cells in the G0/G1 phase[1].
EGFR-IN-219 (24 h) acts as a potent EGFR inhibitor in A549 cells with an IC50 of 2.68 μM, exhibiting 8.3-fold stronger EGFR inhibitory potency and 12.7-fold stronger cytotoxic activity than Erlotinib (HY-50896)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549
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Concentration:IC50 concentration
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Incubation Time:24 h
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Result:Induced 7.13% early apoptosis and 1.60% late apoptosis in A549 cells.
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Cell Line:A549
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Concentration:IC50 concentration
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Incubation Time:24 h
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Result:Induced cell cycle arrest with 65.23% of cells in G0/G1 phase, 20.44% in S phase, and 8.69% in G2/M phase.
Chemical Information
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Molecular Weight 447.26
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Formula C17H11BrN4O4S
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SMILES
O=[N+](C1=CC=C(C2=CSC(N/N=C/C3=C(Br)C=C(OCO4)C4=C3)=N2)C=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-219 Related Classifications
HY-189466 Related Classifications
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